DRUG DELIVERY TO THE PROXIMAL COLON
DRUG DELIVERY TO THE PROXIMAL COLON
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DOI：
10.1111/j.2042-7158.1985.tb04992.x
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发表时间：
1985-01-01
影响因子：
3.3
通讯作者：
WOOD, E
中科院分区：
文献类型：
--
作者：
HARDY, JG;WILSON, CG;WOOD, E
在六名健康志愿者的胃肠道中监测了胶囊和多颗粒颗粒系统的传输。两种制剂一起通过胃和小肠，平均在给药后4小时到达结肠。在结肠内，微丸以比胶囊更慢的速度分散和移动。大肠运输时间在受试者间存在相当大的差异。研究结果从给药到结肠的角度进行了讨论。
The transits of a capsule and a multiparticulate pellet system have been monitored through the gastrointestinal tract in six healthy volunteers. Both preparations moved together through the stomach and small intestine, reaching the colon, on average, 4 h after dosing. Within the colon the pellets dispersed and moved at a slower rate than the capsule. There was considerable intersubject variability in the large bowel transit times. The findings are discussed in terms of drug delivery to the colon.