Effects of sesamin and alpha-tocopherol, individually or in combination, on the polyunsaturated fatty acid metabolism, chemical mediator production, and immunoglobulin levels in Sprague-Dawley rats.
Effects of sesamin and alpha-tocopherol, individually or in combination, on the polyunsaturated fatty acid metabolism, chemical mediator production, and immunoglobulin levels in Sprague-Dawley rats.
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芝麻素和α-生育酚单独或组合对斯普拉格道利大鼠多不饱和脂肪酸代谢、化学介质产生和免疫球蛋白水平的影响。
DOI：
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
Michihiro Sugano
中科院分区：
文献类型：
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作者：
J. Gu;Y. Wakizono;Akira Tsujita;Beong Ou Lim;M. Nonaka;Koji Yamada;Michihiro Sugano
以0.5%的芝麻素和α-生育酚联合饲喂SD大鼠3周后，各组织磷脂酰胆碱中20：4N-6和22：5N-6的比例有下降趋势，而18：2N-6的比例有增加的趋势，提示亚油酸的代谢受到干扰。这种饮食操作显著减少了肺中白三烯C4的产生，脾中白三烯B4的产生，以及血浆组胺水平的降低。同时给予芝麻素和α-生育酚可显著增加肠系膜淋巴结淋巴细胞产生的IgA、Ig G和Ig M，而使Ig E水平有降低的趋势。单独喂食这些化合物，这些效果并不一定明显。因此，芝麻素和α-生育酚联合使用将有效地调节二十烷类化合物的产生和改善免疫功能。
Feeding sesamin and alpha-tocopherol in combination, both at the 0.5% dietary level, to Sprague-Dawley rats for 3 weeks resulted in a trend toward decreasing the proportion of 20:4n-6 and 22:5n-6 and increasing that of 18:2n-6 in phosphatidylcholine from various tissues, suggesting interference with the metabolism of linoleic acid. This dietary manipulation significantly reduced the production of leukotriene C4 in the lung, the splenic production of leukotriene B4, and reduction of the plasma histamine level. Simultaneous administration of sesamin and alpha-tocopherol significantly increased the production of IgA, IgG, and IgM by mesenteric lymph node lymphocytes, while the IgE level tended to be reduced. These effects were not necessarily apparent by feeding these compounds separately. Thus, sesamin and alpha-tocopherol in combination would be effective for regulating the eicosanoid production and modifying the immune function.