Influence of genetic and environmental factors on oral diseases and function in aged twins
Influence of genetic and environmental factors on oral diseases and function in aged twins
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DOI：
10.1111/joor.12228
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发表时间：
2015-01-01
影响因子：
2.9
通讯作者：
Maeda, Y.
中科院分区：
文献类型：
--
作者：
Kurushima, Y.;Ikebe, K.;Maeda, Y.
本研究旨在量化遗传和环境因素对双胞胎口腔疾病和功能的影响。参与者为中老年双胞胎，116对同卵和16对异卵，平均年龄为661±103岁（SD）。记录牙齿数量、蛀牙、补牙和缺牙百分比以及牙周状况，作为口腔疾病的指标。上、下牙弓宽度作为形态学指标。此外，刺激唾液流量、咬合力和咀嚼性能作为口腔功能的指标。对同卵双胞胎和异卵双胞胎进行单因素遗传分析，以检测每个结果的最适合的结构方程模型。牙数和牙周状况均符合由共同环境因素和独特环境因素组成的模型。蛀牙、补牙和缺牙的形态特征和口腔功能测量值符合遗传因素和独特环境因素组成的模型。各项指标的模型拟合表明，牙周病主要受环境因素的影响，而形态学和口腔功能则受遗传和环境因素的双重影响。
This study was conducted to quantify the genetic and environmental contributions to oral disease and function in twins. Participants were middle-aged and old twins, 116 monozygotic and 16 dizygotic pairs whose mean age was 661 +/- 103 (SD) years. Number of teeth, percentage of decayed, filled and missing teeth and periodontal status were recorded as indicators of oral disease. The widths of upper and lower dental arch served as indicators of morphological figures. Furthermore, stimulated salivary flow rate, occlusal force and masticatory performance were measured as indicators of oral function. Univariate genetic analysis with monozygotic and dizygotic twin pairs was conducted to detect the fittest structural equation model of each outcome. Both number of teeth and periodontal status fitted the model composed of common environmental factor and unique environmental factor. Decayed, filled and missing teeth, morphological figures and measurements of oral function fitted the model composed of additive genetic factor and unique environmental factor. The model fitting of each measurement suggested that periodontal disease was mainly affected by environmental factors, while morphological figures and oral functions were influenced by both genetic and environmental factors.