NIS‐Mediated Intramolecular sp 3 C−H Oxidation of 2‐Alkyl‐Substituted Benzamides
NIS‐Mediated Intramolecular sp 3 C−H Oxidation of 2‐Alkyl‐Substituted Benzamides
复制标题
NIS-介导的 2-烷基-取代苯甲酰胺的分子内 sp 3 C-H 氧化
DOI：
10.1002/ejoc.202200505
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发表时间：
2022
影响因子：
2.8
通讯作者：
Lingang Wu
中科院分区：
文献类型：
--
作者：
Lei Sun;Jichun Cui;Shaozhen Nie;Lei Xie;Yanlan Wang;Lingang Wu
In this work, we describe theN‐iodosuccinimide‐mediated benzyl sp3C−H oxidation of 2‐alkyl‐substituted benzamide derivatives. This Hofmann‐Löffler‐Freytag (HLF) type reaction involving intramolecular sp3C−O bond formation differs from the construction of the C−N bond in the classic and modified HLF reactions. This reaction proceeded smoothly via 1,5‐hydrogen atom transfer of N‐centered radicals directly afforded by in situ N−I bond generation, providing iminoisobenzofuran derivatives in moderate to excellent yields with exclusive chemoselectivity.
