Alcohol consumption and risk of bladder cancer in Los Angeles County
Alcohol consumption and risk of bladder cancer in Los Angeles County
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DOI：
10.1002/ijc.22743
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发表时间：
2007-08-15
影响因子：
6.4
通讯作者：
Gago-Dominguez, Manuela
中科院分区：
文献类型：
--
作者：
Jiang, Xuejuan;Castelao, J. Esteban;Gago-Dominguez, Manuela
酒精饮料在膀胱癌发生中的作用仍不清楚，不同研究的证据相互矛盾。我们研究了饮酒与膀胱癌之间的关系，以及饮酒与其他暴露之间的潜在相互作用。在洛杉矶县进行的一项基于人群的病例对照研究中，采访了 1,586 对病例及其匹配的社区对照。分析数据以确定膀胱癌风险是否因饮酒而不同，以及不同的酒精饮料是否有不同的影响。膀胱癌的风险随着饮酒频率（趋势 p = 0.003）和饮酒持续时间（趋势 p = 0.017）的增加而降低。每天饮酒超过 4 杯的受试者患膀胱癌的风险比从不喝任何酒精饮料的受试者低 32%（比值比，0.68；95% 置信区间，0.52-0.90）。啤酒（趋势 p = 0.002）和葡萄酒（趋势 p = 0.054）的消费与膀胱癌风险降低相关，而烈性酒则不然。风险的降低主要体现在经常小便的短期吸烟者身上。饮酒与膀胱癌风险降低密切相关。酒精饮料的类型、吸烟和排尿频率会改变效果。 (c) 2007 年 Wiley-Liss, Inc.
The role of alcoholic beverages in bladder carcinogenesis is still unclear, with conflicting evidence from different studies. We investigated the relationship between alcohol consumption and bladder cancer, and the potential interaction between alcohol consumption and other exposures. In a population-based case-control study conducted in Los Angeles County, 1,586 pairs of cases and their matched neighborhood controls were interviewed. Data were analyzed to determine whether bladder cancer risk differs by alcohol consumption, and whether different alcoholic beverages have different effects. The risk of bladder cancer decreased with increasing frequency (p for trend = 0.003) and duration of alcohol consumption (p for trend = 0.017). Subjects who drank more than 4 drinks per day had a 32% lower (odds ratio, 0.68; 95% confidence interval, 0.52-0.90) risk of bladder cancer than those who never drank any alcoholic beverage. Beer (p for trend = 0.002) and wine (p for trend = 0.054) consumption were associated with reduced risk of bladder cancer, while hard liquor was not. The reduction in risk was mostly seen among shorter-term smokers who urinated frequently. Alcohol consumption was strongly associated with a reduced risk of bladder cancer. The effect was modified by the type of alcoholic beverage, cigarette smoking and frequency of urination. (c) 2007 Wiley-Liss, Inc.