A novel "HIV salience and Perception" scale is associated with PrEP dispensing and adherence among adolescent girls and young women in Kampala, Uganda.
A novel "HIV salience and Perception" scale is associated with PrEP dispensing and adherence among adolescent girls and young women in Kampala, Uganda.
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一种新颖的“艾滋病毒显着性和感知”量表与乌干达坎帕拉少女和年轻女性的 PrEP 分发和依从性相关。
DOI：
10.1007/s10461-022-03762-x
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发表时间：
2023
影响因子：
4.4
通讯作者：
Heffron,Renee
中科院分区：
文献类型：
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作者：
Velloza,Jennifer;Mujugira,Andrew;Muwonge,Timothy;Boyer,Jade;Nampewo,Olivia;Badaru,Josephine;Ssebuliba,Timothy;Stalter,RandyM;Stein,Gabrielle;Baeten,JaredM;Celum,Connie;Heffron,Renee
艾滋病毒风险低是非洲少女和年轻妇女有效使用暴露前预防（PrEP）的一个障碍。单项风险感知措施是污名化和疏远AGYW，可能无法预测PrEP的使用。需要一种工具来捕捉与AGYW之间PrEP使用相一致的感知艾滋病毒风险和显著性的领域。这项HIV PrEP研究在乌干达的坎帕拉进行。我们开发并试用了9项“艾滋病毒显著性和感知”（HPS）量表（范围：9-36）;分数越高表明对艾滋病毒的易感性越高。我们管理的规模乌干达AGYW参与正在进行的队列研究，在登记，一个，三个月和六个月。每季度测量一次PrEP分发，每天通过Wisepill测量依从性（高依从性：≥80%的预期药瓶开口）。我们评估了量表性能，并使用广义估计方程来确定量表评分和PrEP使用之间的关联。在499名AGYW中，54.1%的样本年龄≥ 20岁（范围：16-25岁）。中位HPS评分为18（范围：8-33; α = 0.77）。在整个队列和仅在≥ 20岁人群中（aRR = 1.10; 95% CI = 1.03 - 1.19; p值= 0.01），较高的评分与PrEP分发相关（aRR = 1.07/分增加; 95% CI = 1.01 - 1.13; p值= 0.02）。我们没有观察到量表评分和PrEP依从性之间的关联。AGYW在新的HPS量表上得分较高的患者更有可能在6个月内开始并获得PrEP补充。该量表可以捕获PrEP分配的驱动因素，并可以为AGYW提供PrEP交付和咨询。
Low perceived HIV risk is a barrier to effective pre-exposure prophylaxis (PrEP) use among African adolescent girls and young women (AGYW). Single-item risk perception measures are stigmatizing and alienating to AGYW and may not predict PrEP use. There is a need for a tool capturing domains of perceived HIV risk and salience that align with PrEP use among AGYW. This HIV PrEP study was conducted in Kampala, Uganda. We developed and piloted the 9-item “HIV Salience and Perception” (HPS) scale (range: 9–36); higher scores indicate beliefs of higher vulnerability to HIV. We administered the scale to Ugandan AGYW participating in an ongoing cohort study at enrollment, one, three and six months. PrEP dispensing was measured quarterly and adherence was measured daily via Wisepill (high adherence: ≥80% of expected pill bottle openings). We assessed scale performance and used generalized estimating equations to determine associations between scale score and PrEP use. Among 499 AGYW, 54.1% of our sample was ≥ 20 years (range:16–25). The median HPS score was 18 (range:8–33; α = 0.77). Higher score was associated with PrEP dispensing (aRR = 1.07 per point increase; 95% CI = 1.01–1.13; p-value = 0.02) in the overall cohort and among only those ≥ 20 years (aRR = 1.10; 95% CI = 1.03–1.19; p-value = 0.01). We did not observe an association between scale score and PrEP adherence. AGYW scoring higher on a novel HPS scale were more likely to initiate and obtain PrEP refills through 6 months. This scale may capture drivers of PrEP dispensing and could inform PrEP delivery and counseling for AGYW.
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DOI：
10.1016/s2352-3018(17)30156-x
发表时间：
2018-03
期刊：
The lancet. HIV
影响因子：
--
作者：
Bekker LG;Roux S;Sebastien E;Yola N;Amico KR;Hughes JP;Marzinke MA;Hendrix CW;Anderson PL;Elharrar V;Stirratt M;Rooney JF;Piwowar-Manning E;Eshleman SH;McKinstry L;Li M;Dye BJ;Grant RM;HPTN 067 (ADAPT) study team
通讯作者：
HPTN 067 (ADAPT) study team
影响因子：
3.7
作者：
Warren EA;Paterson P;Schulz WS;Lees S;Eakle R;Stadler J;Larson HJ
通讯作者：
Larson HJ
影响因子：
6
作者：
Corneli, Amy L;McKenna, Kevin;Agot, Kawango
通讯作者：
Agot, Kawango
影响因子：
158.5
作者：
Thigpen, Michael C.;Kebaabetswe, Poloko M.;Brooks, John T.
通讯作者：
Brooks, John T.
影响因子：
4.4
作者：
Kutner BA;King KM;Dorsey S;Creegan E;Simoni JM
通讯作者：
Simoni JM