Prognostic significance of VEGF immunohistochemical expression and tumor angiogenesis in head and neck squamous cell carcinoma
Prognostic significance of VEGF immunohistochemical expression and tumor angiogenesis in head and neck squamous cell carcinoma
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DOI：
10.1007/s00432-005-0003-6
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发表时间：
2005-09-01
影响因子：
3.6
通讯作者：
Agnantis, NJ
中科院分区：
文献类型：
--
作者：
Kyzas, PA;Stefanou, D;Agnantis, NJ
目的：肿瘤血管生成对于原发肿瘤的生长和转移的发展至关重要。在引起肿瘤血管生成的因素中，血管内皮生长因子（VEGF）被认为是主要候选因素。我们的目的是评估 VEGF 和肿瘤血管生成在头颈鳞状细胞癌 (HNSCC) 中的预后意义。方法：我们对 69 例 HNSCC 患者进行了回顾性研究，旨在探讨 VEGF 免疫组织化学表达和肿瘤血管生成是否与临床病理参数和结果相关。通过测定微血管密度（MVD）来估计肿瘤血管生成，并定量评估 VEGF 表达。结果：血管内皮生长因子和 MVD 与临床分期具有统计学显着相关性，但与诊断时是否存在淋巴结转移无关。与位于下唇的肿瘤相比，位于口腔和喉部的肿瘤更常表达高 VEGF 免疫染色。在这组患者中，高 VEGF 表达与较高的临床分期和较差的总生存率相关。结论：血管内皮生长因子的表达可能对 HNSCC 患者具有预后意义。
Purpose: Tumor angiogenesis is crucial for both the growth of the primary tumor and the development of metastases. Among the factors causing tumor angiogenesis, vascular endothelial growth factor (VEGF) is considered as a leading candidate. We aimed to assess the prognostic significance of VEGF and tumor angiogenesis in head and neck squamous cell carcinoma (HNSCC). Methods: We performed a retrospective study of 69 patients with HNSCC, in order to investigate whether VEGF immunohistochemical expression and tumor angiogenesis correlate with clinicopathological parameters and outcome. Tumor angiogenesis was estimated by determining microvessel density (MVD), and VEGF expression was assessed quantitatively. Results: Vascular endothelial growth factor and MVD correlated statistically significant with the clinical stage, but not with the presence of lymph node metastasis at the time of diagnosis. Tumors located in the oral cavity and larynx more often expressed high VEGF immunostaining compared with tumors located in the lower lip. High VEGF expression was associated with higher clinical stage and worse overall survival in this cohort of patients. Conclusions: Vascular endothelial growth factor expression may have prognostic significance for patients with HNSCC.