Immunoligic Mechanisms of Multiple Sclerosis
Immunoligic Mechanisms of Multiple Sclerosis
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DOI：
10.1016/j.nic.2008.06.009
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发表时间：
2008-11-01
影响因子：
2.3
通讯作者：
Karandikar, Nitin
中科院分区：
文献类型：
--
作者：
Frohman, Elliot M.;Eagar, Todd;Karandikar, Nitin
多发性硬化症被广泛认为是发达国家年轻人进行性神经功能障碍的最常见原因。当患者经历神经系统损害的急性发作或功能能力的稳步进行性恶化时，临床怀疑该疾病。急性发作的病理生理学被认为与炎症的发展及其后果有关，炎症发生在战略上，通常是离散的中枢神经系统。尽管已经提出了无数的假设来解释导致多发性硬化症的多相炎症事件的偏好和触发的机制基础，但要充分了解产生该疾病及其主要特征的特定事件集和顺序，还有很多工作要做。
Multiple sclerosis is widely recognized as the most commonly identified cause of progressive neurologic disability in young adults throughout the developed world. The disorder is clinically suspected when patients experience either acute attacks of neurologic compromise or instead are afflicted by a steadily progressive deterioration in functional capabilities. The pathophysiology of acute exacerbations is thought to be related to the development of inflammation and its consequences, within strategic and often discrete central nervous system tract systems. Although a myriad of hypotheses have been formulated to explain the underpinnings of the mechanisms that contribute to both the predilection and triggering of the multiphasic inflammatory events that personify multiple sclerosis, much remains to be done to understand fully the specific set and sequence of events that produce the disease and its cardinal features.