Eukaryotic genes of archaebacterial origin are more important than the more numerous eubacterial genes, irrespective of function
Eukaryotic genes of archaebacterial origin are more important than the more numerous eubacterial genes, irrespective of function
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DOI：
10.1073/pnas.1000265107
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发表时间：
2010-10-05
影响因子：
11.1
通讯作者：
McInerney, James O.
中科院分区：
文献类型：
--
作者：
Cotton, James A.;McInerney, James O.
传统的生命树显示真核生物是生物的一个独特谱系，但许多研究表明，第一个真核细胞是嵌合的，来自真细菌（通过古细菌）和古细菌。因此，真核细胞核含有真细菌和古细菌起源的基因，这些基因在真核细胞内具有不同的功能。在这里，我们报告说，古细菌衍生的基因显着更有可能是必不可少的酵母活力，更高的表达，并显着更高度连接和更中心的酵母蛋白质相互作用网络。这些发现与基因是否具有信息功能或操作功能无关，因此真核生物基因与原核生物同源物的许多特征可以用它们的起源而不是它们的功能来解释。两者合计，我们的研究结果表明，古细菌起源的基因在某种意义上更重要的酵母代谢比真细菌起源的基因。这种重要性反映了这些基因作为真核基因组的祖先核组分的起源。
The traditional tree of life shows eukaryotes as a distinct lineage of living things, but many studies have suggested that the first eukaryotic cells were chimeric, descended from both Eubacteria (through the mitochondrion) and Archaebacteria. Eukaryote nuclei thus contain genes of both eubacterial and archaebacterial origins, and these genes have different functions within eukaryotic cells. Here we report that archaebacterium-derived genes are significantly more likely to be essential to yeast viability, are more highly expressed, and are significantly more highly connected and more central in the yeast protein interaction network. These findings hold irrespective of whether the genes have an informational or operational function, so that many features of eukaryotic genes with prokaryotic homologs can be explained by their origin, rather than their function. Taken together, our results show that genes of archaebacterial origin are in some senses more important to yeast metabolism than genes of eubacterial origin. This importance reflects these genes' origin as the ancestral nuclear component of the eukaryotic genome.