Experimental Study of Active Path Block in a Multi-Bifurcated Flow by Microbubble Aggregation
Experimental Study of Active Path Block in a Multi-Bifurcated Flow by Microbubble Aggregation
复制标题
微气泡聚集多分叉流主动路径块的实验研究
DOI：
--
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
T. Chiba
中科院分区：
文献类型：
--
作者：
N. Shigehara;F. Demachi;R. Koda;T. Mochizuki;K. Masuda;S. Ikeda;F. Arai;Y. Miyamoto;T. Chiba
我们之前报道了利用声辐射力主动控制微泡聚集的尝试，声辐射力推动微泡并调节聚集的大小。然而，由于我们使用的是形状简单的人工血管，因此无法预测小通道内的聚集行为，如阻塞血流的概率、栓塞的可能性等。因此，我们设计并制造了一种多分叉的人工血管，用于微泡聚集的产生和主动控制。然后，我们介绍了两种用于产生和推动聚集的超声换能器。首先，我们在流动中产生聚集体来测量它们的大小，并根据超声波的发射持续时间研究它们的变化。然后，我们在人工血管中对聚集体进行控制，以验证其可控性。当超声波停止时，聚集物从血管壁上脱落并向下游流动，被推进到所需的路径，最后被捕获在一个狭窄的路径上。我们在相似的参数下验证了相同的实验，以计算实现路径块的概率。当流速为20 mm/s时，几乎有50%的聚集体被诱导通过所需的路径，聚集体形成的最大概率达到86%。
We previously reported our attempts at the active control of microbubble aggregations using acoustic radiation force, which propels microbubbles and adjusts the size of aggregations. However, because we used simple-shape artificial blood vessels, the behavior of aggregations in a small channel, e.g., the probability to obstruct the bloodstream, and the possibility of embolization, has not been predicted. Thus, we designed and fabricated a multi-bifurcated artificial blood vessel to apply to the production and active control of microbubble aggregations. Then, we introduced two kinds of ultrasound transducers for producing and propelling aggregations. First, we produced aggregations in a flow to measure their size and investigate their variation according to the emission duration of ultrasound. Then, we control the aggregations in an artificial blood vessel to verify their controllability. When ultrasound was stopped, the aggregations flaked off the vessel wall and flowed downstream, were propelled to the desired path, and finally were caught at a narrow path. We verified the same experiment under similar parameters to calculate the probability of realizing a path block. When the flow velocity was 20 mm/s, almost 50% of the aggregations were induced to flow through the desired path and a maximum probability of realizing a path block of 86% was achieved with the formation of aggregations.