Abnormal weight gain with fatigue and stress in early survivorship after childhood brain tumor diagnosis.
Abnormal weight gain with fatigue and stress in early survivorship after childhood brain tumor diagnosis.
复制标题
儿童脑肿瘤诊断后早期生存中体重异常增加并伴有疲劳和压力。
DOI：
10.1111/jspn.12288
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Rice,Marti
中科院分区：
文献类型：
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作者：
Johnson,AnnH;RodgersPhillips,Shameka;Rice,Marti
研究背景儿童期脑肿瘤患者的诊断和治疗涉及后遗症，包括体重异常增加。这种症状通常与疲劳和心血管疾病风险增加有关。儿童肿瘤学小组的建议包括每年监测体重指数（BMI）和心脏代谢合并症;但是，在此情况下，在早期生存期的个体化筛查一直很少受到重视。目的本文的主要目的是描述在早期生存期的幼儿脑肿瘤幸存者样本中异常体重增加及其相关性的发现。设计和方法这项横断面多中心研究包括年龄8-12岁的脑肿瘤幸存者，治疗后不到6年。从美国南部的两个儿科癌症中心方便取样。收集的数据包括BMI，父母报告的睡眠，和儿童报告的疲劳和stress.ResultsThe样本（N= 21）包括儿童谁接受了化疗，放疗，手术治疗儿童脑肿瘤。超重和肥胖类别的BMI超过正常样本，38%达到或超过第85百分位数。疲劳、体重压力、肿瘤位置、颅脑放疗、化疗和复发与临床显著相关。实践意义筛选异常体重增加和相关因素，如疲劳，应开始在儿童脑肿瘤治疗完成后的早期生存期，以促进健康和预防疾病。肥胖测量技术应在未来的临床和研究环境中使用，以改善心脏代谢风险的评估。
BackgroundDiagnosis and treatment for individuals with brain tumors during childhood involves sequelae, including abnormal weight gain. This symptom is commonly clustered with fatigue and increased risk for cardiovascular disease. Children's Oncology Group recommendations include annual surveillance of body mass index (BMI) and cardiometabolic comorbidities; however, there has been little emphasis on individualized screening early in survivorship.PurposeThe primary purpose of this paper is to describe the findings of abnormal weight gain and its correlates in a sample of young childhood brain tumor survivors during early survivorship.Design and MethodsThis cross‐sectional multi‐site study included brain tumor survivors of ages 8–12 years who were less than 6 years posttreatment. Convenience sampling from two pediatric cancer centers in the southern United States was utilized. Data collected included BMI, parent report of sleep, and child report of fatigue and stress.ResultsThe sample (N= 21) consisted of children who had received chemotherapy, radiation treatment, and surgery for childhood brain tumor. BMI in overweight and obese categories exceeded normative samples with 38% at or above the 85th percentile. There were clinically significant relationships with fatigue, stress about weight, tumor location, cranial radiation, chemotherapy, and recurrencePractice ImplicationsScreening for abnormal weight gain and related factors, such as fatigue should begin early in survivorship after childhood brain tumor treatment completion with the aim of health promotion and disease prevention. Adiposity measurement techniques should be utilized in future clinical and research settings to improve assessment of cardiometabolic risk.