Preventing Human Immunodeficiency Virus Infection Among Sexual Assault Survivors in Cape Town, South Africa: An Observational Study
Preventing Human Immunodeficiency Virus Infection Among Sexual Assault Survivors in Cape Town, South Africa: An Observational Study
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DOI：
10.1007/s10461-011-9892-3
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发表时间：
2012-05-01
影响因子：
4.4
通讯作者：
Denny, Lynette A.
中科院分区：
文献类型：
--
作者：
Roland, Michelle E.;Myer, Landon;Denny, Lynette A.
我们描述了 131 名南非性侵犯幸存者接受艾滋病毒暴露后预防 (PEP) 的情况。虽然完成的中位天数为 27 天（IQR 27、28），但 34% 的人停止了 PEP 或错过了服药。控制基线症状后，PEP 与症状无关（OR = 1.30，95% CI = 0.66，2.64）。与无保护性行为相关的因素包括之前的无保护性行为（OR = 6.46，95% CI = 3.04，13.74）、袭击发生后的时间（OR = 1.33，95% CI = 1.12，1.57）和年龄（OR = 1.30，95% CI = 1.08，1.57）。创伤咨询具有保护作用（OR = 0.18，95% CI = 0.05，0.58）。 6 个月内观察到 4 例血清转化（风险 = 3.7%，95% CI = 1.0，9.1）。积极的后续行动对于增加 PEP 完成的可能性并解决幸存者的心理健康和艾滋病毒风险需求是必要的。应提供依从性干预措施和有针对性的降低风险咨询，以尽量减少艾滋病毒感染。
We describe 131 South African sexual assault survivors offered HIV post-exposure prophylaxis (PEP). While the median days completed was 27 (IQR 27, 28), 34% stopped PEP or missed doses. Controlling for baseline symptoms, PEP was not associated with symptoms (OR = 1.30, 95% CI = 0.66, 2.64). Factors associated with unprotected sex included prior unprotected sex (OR = 6.46, 95% CI = 3.04, 13.74), time since the assault (OR = 1.33, 95% CI = 1.12, 1.57) and age (OR = 1.30, 95% CI = 1.08, 1.57). Trauma counseling was protective (OR = 0.18, 95% CI = 0.05, 0.58). Four instances of seroconversion were observed by 6 months (risk = 3.7%, 95% CI = 1.0, 9.1). Proactive follow-up is necessary to increase the likelihood of PEP completion and address the mental health and HIV risk needs of survivors. Adherence interventions and targeted risk reduction counseling should be provided to minimize HIV acquisition.