Quercetin and doxorubicin co-encapsulated biotin receptor-targeting nanoparticles for minimizing drug resistance in breast cancer.
Quercetin and doxorubicin co-encapsulated biotin receptor-targeting nanoparticles for minimizing drug resistance in breast cancer.
复制标题
槲皮素和阿霉素共同封装的生物素受体靶向纳米颗粒可最大限度地减少乳腺癌的耐药性
DOI：
10.18632/oncotarget.8607
复制
发表时间：
2016-05-31
期刊：
影响因子：
--
通讯作者：
Li G
中科院分区：
文献类型：
--
作者：
Lv L;Liu C;Chen C;Yu X;Chen G;Shi Y;Qin F;Ou J;Qiu K;Li G
化疗药物与化疗增敏剂的组合已经成为显示多药耐药（MDR）的癌症的有希望的策略。在此，我们描述了通过使用生物素修饰的聚（乙二醇）-b-聚（ε-己内酯）纳米粒包裹化疗药物阿霉素和化疗增敏剂槲皮素（BNDQ），同时靶向递送两种药物到肿瘤细胞。接下来，研究了BNDQ在体外和体内逆转MDR的潜在能力。研究表明，BNDQ被阿霉素耐药的MCF-7乳腺癌细胞（MCF-7/ADR细胞）比用游离药物、单一药物负载的纳米颗粒或非生物素修饰的纳米颗粒处理的细胞更有效地吸收，且流出量更少。BNDQ对MCF-7/ADR细胞P-糖蛋白的活性和表达均有明显的抑制作用。更重要的是，在所有组中，它在体外和体内都引起MCF-7/ADR乳腺癌细胞中多柔比星耐药性的显著降低。总的来说，这项研究表明，BNDQ在治疗耐药乳腺癌方面具有潜在的作用。
The combination of a chemotherapeutic drug with a chemosensitizer has emerged as a promising strategy for cancers showing multidrug resistance (MDR). Herein we describe the simultaneous targeted delivery of two drugs to tumor cells by using biotin-decorated poly(ethylene glycol)-b-poly(ε-caprolactone) nanoparticles encapsulating the chemotherapeutic drug doxorubicin and the chemosensitizer quercetin (BNDQ). Next, the potential ability of BNDQ to reverse MDR in vitro and in vivo was investigated. Studies demonstrated that BNDQ was more effectively taken up with less efflux by doxorubicin-resistant MCF-7 breast cancer cells (MCF-7/ADR cells) than by the cells treated with the free drugs, single-drug–loaded nanoparticles, or non-biotin–decorated nanoparticles. BNDQ exhibited clear inhibition of both the activity and expression of P-glycoprotein in MCF-7/ADR cells. More importantly, it caused a significant reduction in doxorubicin resistance in MCF-7/ADR breast cancer cells both in vitro and in vivo, among all the groups. Overall, this study suggests that BNDQ has a potential role in the treatment of drug-resistant breast cancer.
登录
查看更多内容
DOI：
10.3390/molecules15020857
发表时间：
2010-02-09
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Borska S;Sopel M;Chmielewska M;Zabel M;Dziegiel P
通讯作者：
Dziegiel P
影响因子：
4.6
作者：
Misra, Ranjita;Sahoo, Sanjeeb K.
通讯作者：
Sahoo, Sanjeeb K.
影响因子：
3.1
作者：
Jing Shen;Weijing Zhang;Yunfeng Zhu
通讯作者：
Yunfeng Zhu
基于肝素修饰聚L-丙交酯接枝聚乙烯亚胺阳离子纳米粒的核壳药物载体共同递送阿霉素和姜黄素增强4T1乳腺癌抗癌活性
影响因子：
2.9
作者：
Guo, Qingfa;Li, Xiaolu;Qian, Zhiyong
通讯作者：
Qian, Zhiyong
基于甲氧基聚乙二醇-胆固醇缀合物的胶束用于水溶性差的药物的受控和靶向药物输送
影响因子：
2.9
作者：
Li, Junming;He, Zhiyao;Song, Xiangrong
通讯作者：
Song, Xiangrong