Requirement of Ras-Dependent Pathways for Activation of the Transforming Growth Factor β3 Promoter by Estradiol**This work was supported by the Canadian Institutes of Health Research and the National Cancer Institute of Canada through the Canadian Breast Cancer Research Initiative program.
Requirement of Ras-Dependent Pathways for Activation of the Transforming Growth Factor β3 Promoter by Estradiol**This work was supported by the Canadian Institutes of Health Research and the National Cancer Institute of Canada through the Canadian Breast Cancer Research Initiative program.
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雌二醇激活转化生长因子 β3 启动子所需的 Ras 依赖性途径**这项工作得到了加拿大健康研究所和加拿大国家癌症研究所通过加拿大乳腺癌研究计划的支持。
作者：
D. Lu;Vincent Gigue Re
It has been previously observed that the transforming growth factorβ 3 (TGFβ3) gene can be activated by both estradiol (E2) and selective estrogen receptor modulators (SERMs) in vivo but that only SERMs have a potent stimulatory effect on the TGFβ3 promoter in cultured cells. We demonstrate in this report that E2 can act also as a potent inducer of the TGFβ3 promoter via a novel and specific estrogen receptor (ER)α-mediated mechanism. Our results show that treatment with epidermal growth factor or transfection of a constitutively active Ras mutant allows E2 to induce the TGFβ3 promoter via ERα in cotransfected HeLa and osteosarcoma MG63 cells. Both protein kinase C (PKC) and mitogen-activated protein kinase (MAPK) inhibitors can block the combined stimulatory effect of E2 and epidermal growth factor/Ras. However, E2 induction of the TGFβ3 promoter was found to be unaffected by mutation of ERα serine 118, a well-characterized target of MAPK. Progressive deletion analysis of the ERα amino-terminal region de...
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DOI：
10.1016/s0021-9258(17)40767-8
发表时间：
1994-06
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
V. Krishnan;Xiahong Wang;S. Safe
通讯作者：
V. Krishnan;Xiahong Wang;S. Safe
雌激素受体通过两种不同的机制增强 AP-1 活性，这两种机制对受体反式激活功能有不同的要求。
DOI：
10.1210/mend.13.10.0357
发表时间：
1999
期刊：
Molecular endocrinology (Baltimore, Md.)
影响因子：
--
作者：
Webb,P;Nguyen,P;Valentine,C;Lopez,GN;Kwok,GR;McInerney,E;Katzenellenbogen,BS;Enmark,E;Gustafsson,JA;Nilsson,S;Kushner,PJ
通讯作者：
Kushner,PJ
影响因子：
56.9
作者：
GREENE, GL;GILNA, P;SHINE, J
通讯作者：
SHINE, J
雌激素、环磷酸腺苷和胰岛素样生长因子-I 刺激雌激素受体介导的转录和改变大鼠子宫雌激素受体的磷酸化状态。
DOI：
10.1210/mend.7.6.7689695
发表时间：
1993
期刊：
Molecular endocrinology (Baltimore, Md.)
影响因子：
--
作者：
Aronica,SM;Katzenellenbogen,BS
通讯作者：
Katzenellenbogen,BS