The impact of litter effects on dose-response modeling in teratology.
The impact of litter effects on dose-response modeling in teratology.
复制标题
垃圾效应对畸胎学剂量反应模型的影响。
作者：
L. Kupper;C. Portier;M. D. Hogan;E. Yamamoto
剂量-反应模型拟合致畸数据涉及窝，以产生致畸风险的估计正在受到越来越多的关注，作为一个潜在的替代“安全系数”的风险估计方法。在本文中，我们利用β-二项分布引入不同程度的内相关性，并为说明的目的，考虑一个逻辑剂量反应模型，描述了对数的风险作为一个直线函数的ln（剂量）。通过模拟研究了截距和斜率的最大似然估计的偏差和（精确和渐近）方差随样本内相关结构的变化。
The fitting of dose-response models to teratology data involving littermates in order to generate estimates of teratogenic risk is receiving increasing attention as a potential alternative to the "safety-factor" approach to risk estimation. In this paper, we utilize the beta-binomial distribution to introduce varying degrees of intralitter correlation, and, for purposes of illustration, consider a logistic dose-response model that describes the logit of risk as a straight-line function of ln(dose). The biases and (exact and asymptotic) variances of the maximum likelihood estimators of the intercept and slope are studied by simulation as a function of the intralitter correlation structure.