Studying the Impact of the Genetic Polymorphisms of Chemokines on the Arterial Pressure Level and Kidney Function in Patient with the Chronic Glomerulonephritis.
Studying the Impact of the Genetic Polymorphisms of Chemokines on the Arterial Pressure Level and Kidney Function in Patient with the Chronic Glomerulonephritis.
复制标题
研究趋化因子基因多态性对慢性肾小球肾炎患者动脉压水平和肾功能的影响。
DOI：
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
F. Sobyanin
中科院分区：
文献类型：
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作者：
I. A. Yushina;E. Vasil;F. Sobyanin
对238例慢性肾小球肾炎患者和462例正常对照者的趋化因子基因（+1931的G/MIP 1 β、A/G I-TAC（rs 4512021）、-403A/G RANTES、C/G MCP 1（rs 2857657）、-801G/A SDF 1）多态性与动脉高压和肾功能不全的关系进行了研究。已确定遗传标志物AGI-TAC（rs 4512021）是慢性肾小球肾炎患者发生重度动脉高压的危险因素（OR= 1.65），基因型AGI-TAC和AGI-TAC是慢性肾小球肾炎患者发生重度动脉高压的危险因素。
The associations of polymorphisms of the chemokine genes (+1931А/Т MIP1β, A/G I-TAC (rs4512021), -403A/G RANTES, C/G MCP1 (rs2857657), -801G/A SDF1) with arterial hypertension and renal insufficiency were investigated in 238 patients with chronic glomerulonephritis and 462 individuals of the control group. It has been established that the genetic marker А I-TAC (rs 4512021) is the risk factor for genesis of the severe arterial hypertension at the chronic glomerulonephritis (OR=1,65) and the genotypes АА and AG I-TAC are the