Reconstruction of fluorescence/bioluminescence sources in biological medium with spatial filter.
Reconstruction of fluorescence/bioluminescence sources in biological medium with spatial filter.
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DOI：
10.1364/oe.18.013151
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发表时间：
2010-06
期刊：
影响因子：
3.8
通讯作者：
S. Okawa;Yukio Yamada
中科院分区：
文献类型：
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作者：
S. Okawa;Yukio Yamada
我们提出了一种新的方法，通过使用空间滤波器和连续更新过程的前向模型的荧光/生物发光扩散光学层析重建的发射源分布。空间滤波器将一组测量数据转换为感兴趣位置处的单个源强度，并且通过使用估计的源强度来更新正演模型。该更新过程根据重建源分布忽略了重建源的位置，提高了重建图像的空间分辨率。基于奇异值分解，估计的源还用于减少噪声引起的伪影。数值实验表明，本文方法与传统的最小二乘法和代数重构法相比，具有一定的优越性。最后，通过对二维和三维几何形状的模拟，定量地给出了该方法实际使用的标准。
We propose a new method for reconstruction of emitting source distributions by use of a spatial filter and a successive updating process of the forward model for fluorescence/bioluminescence diffuse optical tomography. The spatial filter transforms a set of the measurement data to a single source strength at a position of interest, and the forward model is updated by use of the estimated source strengths. This updating process ignores the dispensable source positions from reconstruction according to the reconstructed source distribution, and the spatial resolution of the reconstructed image is improved. The estimated sources are also used for the reduction of artifacts induced by noises based on the singular value decomposition. Some numerical experiments show the advantages of the proposed method by comparing the present results with those obtained by the conventional methods of the least squares method nd Algebraic Reconstruction Technique. Finally the criteria for practical use of the method are quantitatively presented by the simulations for 2D and 3D geometries.