Cell Therapy From Bench to Bedside Translation in CNS Neurorestoratology Era.
Cell Therapy From Bench to Bedside Translation in CNS Neurorestoratology Era.
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DOI：
10.3727/215517910x516673
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发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Sanberg P
中科院分区：
文献类型：
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作者：
Huang H;Chen L;Sanberg P
细胞生物学、神经损伤和修复方面的最新进展以及神经恢复干预措施的发展是增加乐观情绪的基础。基于脱髓鞘和髓鞘再生、变性和再生、损伤和修复、功能丧失和恢复过程的复杂性，预期有效的治疗方法将需要包括神经可塑性、免疫调节、神经保护、神经修复、神经替代和神经调节的策略的组合。基于细胞的修复治疗已成为一种新的趋势，越来越多的全球数据有力地证明了它在CNS疾病中具有关键的治疗价值。此外，临床上已在一定程度上实现了中枢神经系统的功能恢复。到目前为止，成功用于临床前实验和/或临床试验/治疗的细胞包括胎儿/胚胎脑和脊髓组织，干细胞，（胚胎干细胞、神经干细胞/祖细胞、造血干细胞、脂肪来源的成体干细胞/前体细胞、皮肤来源的前体细胞、诱导多能干细胞）、神经胶质细胞（雪旺细胞、少突胶质细胞、嗅鞘细胞、星形胶质细胞、小胶质细胞、伸长细胞）、神经元细胞（各种表型神经元和浦肯野细胞），来源于骨髓、脐带和脐带血的间充质基质细胞，来源于视网膜和羊膜层的上皮细胞、月经血来源的干细胞、支持细胞和活性巨噬细胞等。
Recent advances in cell biology, neural injury and repair, and the progress towards development of neurorestorative interventions are the basis for increased optimism. Based on the complexity of the processes of demyelination and remyelination, degeneration and regeneration, damage and repair, functional loss and recovery, it would be expected that effective therapeutic approaches will require a combination of strategies encompassing neuroplasticity, immunomodulation, neuroprotection, neurorepair, neuroreplacement, and neuromodulation. Cell-based restorative treatment has become a new trend, and increasing data worldwide have strongly proven that it has a pivotal therapeutic value in CNS disease. Moreover, functional neurorestoration has been achieved to a certain extent in the CNS clinically. Up to now, the cells successfully used in preclinical experiments and/or clinical trial/treatment include fetal/embryonic brain and spinal cord tissue, stem cells (embryonic stem cells, neural stem/progenitor cells, hematopoietic stem cells, adipose-derived adult stem/precursor cells, skin-derived precursor, induced pluripotent stem cells), glial cells (Schwann cells, oligodendrocyte, olfactory ensheathing cells, astrocytes, microglia, tanycytes), neuronal cells (various phenotypic neurons and Purkinje cells), mesenchymal stromal cells originating from bone marrow, umbilical cord, and umbilical cord blood, epithelial cells derived from the layer of retina and amnion, menstrual blood-derived stem cells, Sertoli cells, and active macrophages, etc. Proof-of-concept indicates that we have now entered a new era in neurorestoratology.