Functional MRI and Structural Connectome Analysis of Language Networks in Japanese-English Bilinguals
Functional MRI and Structural Connectome Analysis of Language Networks in Japanese-English Bilinguals
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DOI：
10.1016/j.neuroscience.2020.01.030
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发表时间：
2020-04-01
期刊：
影响因子：
3.3
通讯作者：
Arai, Hajime
中科院分区：
文献类型：
--
作者：
Mitsuhashi, Takumi;Sugano, Hidenori;Arai, Hajime
本研究旨在阐明神经可塑性在语言中的作用机制。我们假设，双语者所发生的变化可能反映了第二语言习得的机制，并模拟了与语言相关的神经可塑性。我们比较了单语者和双语者与听故事相关的血流动力学调节和皮质下纤维网络的空间特征。参与者是日语单语者和以日语为第一语言的日英双语者。根据习得年龄是否早于7岁以后，我们将双语者分为早期和晚期双语者。我们应用组间分析来研究：(1)基于区块的功能磁共振成像(FMRI)在听故事时的血氧水平依赖反应(BOLD)反应；(2)DTI测量特定边缘之间的纤维数量(NOF)。在功能磁共振成像中，两个双语样本在右侧壳核和双侧颞上回显示出比日本单语者更大的大胆反应(BRS)。晚期双语者右侧前颞叶和左侧内侧顶叶的BRS明显大于早期双语者。在DTI中，早期双语者右侧壳核和中央前回的NOF高于单语者和晚期双语者。晚期双语者左侧颞叶上回和边缘上回之间的NOF低于单语者和早期双语者。早期双语者加强右侧壳核和中央前回之间的皮质下纤维网络，并激活右侧壳核以获得替代语言功能。我们的结论是，这些关键的大脑区域和皮质下纤维网络可能有助于语言的神经可塑性。(C)2020作者。爱思唯尔有限公司代表伊布罗出版。
We aimed to clarify the mechanisms of neural plasticity involved in language. We hypothesized that alterations which occur in bilinguals could reflect the mechanisms of acquisition of a second language and simulate neural plasticity related to language. We compared spatial characteristics of story listening-related hemodynamic modulations and subcortical fiber networks between monolinguals and bilinguals. Participants were Japanese monolinguals and Japanese-English bilinguals whose first language was Japanese. We divided bilinguals into early and late bilinguals depending on whether the age of acquisition was before after 7 years of age. We applied intergroup analysis to investigate the following: (1) blood oxygen level-dependent response (BOLD) responses during story listening by block-based fMRI; (2) number of fibers (NOFs) between specific edges by DTI. Both bilingual samples showed larger BOLD responses (BRs) in the right putamen and bilateral superior temporal gyri compared to the Japanese monolinguals in fMRI. Late bilinguals demonstrated bigger BRs in the right anterior temporal lobe and left medial parietal lobe than early bilinguals. Early bilinguals showed a higher NOFs between the right putamen and precentral gyrus than monolinguals and late bilinguals in DTI. Late bilinguals showed a lower NOFs between the left superior temporal gyrus and supramarginal gyrus than monolinguals and early bilinguals. Early bilinguals reinforce the subcortical fiber network between the right putamen and precentral gyrus, and activate the right putamen to gain alternative language function. We conclude that these key cerebral regions and subcortical fiber networks could contribute to the neural plasticity of language. (C) 2020 The Authors. Published by Elsevier Ltd on behalf of IBRO.