Case-control study of coffee consumption and the risk of endometrial endometrioid adenocarcinoma
Case-control study of coffee consumption and the risk of endometrial endometrioid adenocarcinoma
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DOI：
10.1097/cej.0b013e3282f0c02c
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发表时间：
2008-08-01
影响因子：
2.4
通讯作者：
Tsuj, Ichiro
中科院分区：
文献类型：
--
作者：
Koizumi, Toshimitsu;Nakaya, Naoki;Tsuj, Ichiro
本研究采用病例对照设计，在日本调查了咖啡消费与子宫内膜类腺癌（EEA）风险之间的关系。这些病例包括来自两个医疗中心的107名年龄小于80岁的妇女，她们经组织病理学诊断患有EEA。从癌症筛查项目的参与者中选择的对照组为214名女性，每例病例选择两名对照组（年龄和居住地区匹配）。一个自我管理的问卷调查，其中包含的问题，以确定饮食和饮料消费，以及生殖史，分发给病例和对照。条件Logistic回归分析用于估计三个咖啡消费水平的EEA的比值比（OR），并对潜在的混杂因素进行调整。咖啡消费量最高三分位数个体的EEA多变量调整OR（2 - 3杯或更多/天）为0.4 [95%置信区间（Cl），0.2-0.9]，中间三分位数病例的置信区间为0.4 [95%置信区间（Cl），0.2-0.9]，（5至6次/周-1杯/天）为0.6（95% CI，0.3-1.2），相对于咖啡消费量最低三分位数的个体（3至4次或更少/周）（趋势P = 0.014）。在绝经后妇女中观察到上述相关性（趋势P = 0.016），但在绝经前妇女中未观察到上述相关性（趋势P = 0.90）。因此，这项研究揭示了咖啡消费量和EEA风险之间的反向剂量反应关系，以及绝经后妇女的强烈相关性，但在绝经前妇女中没有。
This study examined the association between coffee consumption and the risk of endometrial endometrioid adenocarcinoma (EEA) in Japan by a case-control design. The cases consisted of 107 women less than 80 years of age from two medical centers who had been histopathologically diagnosed to have EEA. The controls, selected from the participants of a cancer-screening program, were 214 women, with two controls selected for each case (matched for age and for area of residence). A self-administered questionnaire containing questions to determine dietary and beverage consumption, as well as reproductive history, was distributed to the cases and controls. Conditional logistic regression analysis was used to estimate the odds ratio (OR) of EEA for three levels of coffee consumption with adjustment for potential confounding factors. The multivariate-adjusted OR of EEA for individuals in the highest tertile of coffee consumption (2 to 3 cups or more/day) was 0.4 [95% confidence interval (Cl), 0.2-0.9], and that of cases in the intermediate tertile (5 to 6 times/week-1 cup/day) was 0.6 (95% Cl, 0.3-1.2), relative to the individuals in the lowest tertile of coffee consumption (3 to 4 times or less/week) (P for trend = 0.014). The above association was observed in postmenopausal women (P for trend = 0.016), but not in premenopausal women (P for trend = 0.90). This study thus revealed an inverse dose-response relationship between coffee consumption and the risk of EEA, and its strong association in postmenopausal women but not in premenopausal women.