The development of insulin resistance in brown adipose tissue may impair the acute cold-induced activation of thermogenesis in genetically obese (ob/ob) mice
The development of insulin resistance in brown adipose tissue may impair the acute cold-induced activation of thermogenesis in genetically obese (ob/ob) mice
复制标题
棕色脂肪组织中胰岛素抵抗的发展可能会损害遗传性肥胖（ob/ob）小鼠中急性寒冷诱导的产热激活
DOI：
10.1007/bf01116891
复制
发表时间：
1984
影响因子：
4
通讯作者：
P. Trayhurn
中科院分区：
文献类型：
--
作者：
S. W. Mercer;P. Trayhurn
遗传性肥胖(ob/ob)小鼠在出生第五周期间在棕色脂肪组织中出现胰岛素抵抗。在此之前，出生26天的oh/oh小鼠在急性寒冷暴露期间显示出与棕色脂肪组织线粒体结合的GDP显著增加。当棕色脂肪中的胰岛素抵抗出现时，到35天龄时，对寒冷的GDP结合增加明显减少。对2-脱氧葡萄糖的研究表明，棕色脂肪组织中的胰岛素抵抗可能会限制组织吸收葡萄糖的能力，从而削弱在急性寒冷暴露期间的生热反应。
Genetically obese (ob/ob) mice develop insulin resistance in brown adipose tissue during the fifth week of life. Prior to this, at 26 days of age, oh/oh mice show a substantial increase in GDP binding to brownadipose-tissue mitochondria during acute cold exposure. When insulin resistance in brown fat develops, by 35 days of age, the increase in GDP binding in response to cold is markedly reduced. Studies with 2-deoxyglucose suggest that insulin resistance in brown adipose tissue could impair thermogenic responsiveness during acute cold exposure by limiting the ability of the tissue to take up glucose.