EFFECTS OF THE LIPASE INHIBITORS, TRITON-WR-1339 AND TETRAHYDROLIPSTATIN, ON THE SYNTHESIS AND SECRETION OF LIPIDS BY RAT HEPATOCYTES
EFFECTS OF THE LIPASE INHIBITORS, TRITON-WR-1339 AND TETRAHYDROLIPSTATIN, ON THE SYNTHESIS AND SECRETION OF LIPIDS BY RAT HEPATOCYTES
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DOI：
10.1016/0014-5793(91)80970-e
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发表时间：
1991-07-29
期刊：
影响因子：
3.5
通讯作者：
BRINDLEY, DN
中科院分区：
文献类型：
--
作者：
HERMIER, D;HALES, P;BRINDLEY, DN
将脂肪酶抑制剂Triton WR-1339和四氢脂抑素与大鼠肝细胞孵育。Triton WR-1339使三酰甘油在肝细胞和孵育液中的回收率分别提高了31%和38%。四氢脂抑素可减少新合成的甘油三酯和总三酰甘油在培养基中的积累。这种化合物可能有助于确定涉及细胞内三酰甘油代谢和极低密度脂蛋白分泌的机制。
The lipase inhibitors, Triton WR-1339 and tetrahydrolipstatin, were incubated with rat hepatocytes. Triton WR-1339 increased the recovery of triacylglycerol in the hepatocytes and incubation medium by 31% and 38%, respectively. Tetrahydrolipstatin decreased the accumulation of newly synthesized, and of total triacylglycerol in the medium. This compound might be useful in determining mechanisms involved in intracellular triacylglycerol metabolism and the secretion of very low density lipoproteins.