Single, dual and multiple respiratory virus infections and risk of hospitalization and mortality
Single, dual and multiple respiratory virus infections and risk of hospitalization and mortality
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DOI：
10.1017/s0950268814000302
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发表时间：
2015-01-01
影响因子：
4.2
通讯作者：
Klapper, P. E.
中科院分区：
文献类型：
--
作者：
Goka, E. A.;Vallely, P. J.;Klapper, P. E.
呼吸道病毒感染在全球范围内造成大量住院和死亡。本研究调查了0-105岁患者的单一和多种呼吸道病毒感染与进入普通病房、重症监护室或死亡风险之间的关系（平均值+/- s.d.= 1.000）。244 +/- 241岁），来自英格兰西北部，在2007年1月至2012年6月期间进行了呼吸道病毒感染检测。大多数感染发生在5岁的儿童中。104%（1214/11715）的患者发生双重或多重感染，而896%（10501/11715）的患者发生单一感染。鼻病毒是最常见的合并感染病毒（发生率为695%;合并感染的844/1214）。在多变量logistic回归模型中，多重感染与入住普通病房的风险增加相关[比值比（OR）143，95%可信区间（CI）12-17，P
Respiratory virus infections cause a significant number of hospitalization and deaths globally. This study investigated the association between single and multiple respiratory virus infections and risk of admission to a general ward, intensive care unit or death in patients aged 0-105 years (mean +/- s.d.=244 +/- 241 years), from North West England, that were tested for respiratory virus infections between January 2007 and June 2012. The majority of infections were in children aged 5 years. Dual or multiple infections occurred in 104% (1214/11715) of patients, whereas single infection occurred in 896% (10501/11715). Rhinovirus was the most common co-infecting virus (occurring in 695%; 844/1214 of co-infections). In a multivariate logistic regression model, multiple infections were associated with an increased risk of admission to a general ward [odds ratio (OR) 143, 95% confidence interval (CI) 12-17, P