MORPHOLOGICAL RANGE OF HYPERPLASTIC POLYPS AND CARCINOMAS ARISING IN HYPERPLASTIC POLYPS OF THE STOMACH
MORPHOLOGICAL RANGE OF HYPERPLASTIC POLYPS AND CARCINOMAS ARISING IN HYPERPLASTIC POLYPS OF THE STOMACH
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DOI：
10.1136/jcp.38.6.622
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发表时间：
1985-01-01
影响因子：
3.4
通讯作者：
HATTORI, T
中科院分区：
文献类型：
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作者：
HATTORI, T
对67例增生性息肉的形态学范围进行了研究。这些息肉包括通过内窥镜切除的息肉和在切除的胃中偶然发现的胃溃疡和癌症息肉。增生性息肉基本上由囊状小凹和幽门型腺体组成，内衬与正常胃粘膜相同的细胞。息肉（31）含有其他细胞学成分。18例可见肠上皮化生，肾小管主要由柱状细胞和杯状细胞组成，缺乏潘氏细胞。在11例息肉、9例胃异型增生和2例肠异型增生中发现异型增生，前者包括不规则形状的小凹增生，细胞呈多形立方/柱状，胞浆相对嗜碱性。它们含有胃型粘液素颗粒。后者由非典型小窝组成，小窝由紧密排列的高柱状细胞和小杯状细胞组成，两者都类似于结肠的腺瘤细胞。3例息肉中发现癌，其中1例为肠型腺癌。另2例癌细胞与正常小凹细胞相似，含有胃型粘液颗粒。均为胃型腺癌。
A morphological range of 67 hyperplastic polyps was studied. They included polyps removed endoscopically and polyps found incidentally in resected stomachs with gastric ulcers and cancer. The hyperplastic polyps were essentially composed of cystic foveolae and pyloric type glands, lined by cells identical to those of the normal gastric mucosa. Polyps (31) contained other cytological elements. In 18, intestinal metaplasia was seen; the tubules were mostly composed of columar and goblet cells and lacked Paneth cells. In 11 polyps, 9 cases of gastric dysplasia and 2 cases of intestinal dysplasia, dysplastic changes were found. The former consisted of a proliferation of irregularly shaped pits with pleomorphic cuboidal/columnar cells with relatively basophilic cytoplasm. They contained mucigen granules of a gastric type. The latter consisted of atypical pits composed of closely packed, tall columnar and small goblet cells, both resembling adenomatous cells of the colon. In 3 polyps carcinomas were seen, 1 of which was an intestinal type adenocarcinoma. In the other 2, the cancer cell closely resembled the normal foveolar cells, containing gastric type mucigen granules. They were gastric type adenocarcinomas.