Cytotoxic lavandulyl flavanones from Sophora flavescens
Cytotoxic lavandulyl flavanones from Sophora flavescens
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DOI：
10.1021/np990567x
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发表时间：
2000-05-01
影响因子：
5.1
通讯作者：
Kim, YC
中科院分区：
文献类型：
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作者：
Kang, TH;Jeong, SJ;Kim, YC
从苦参根中分离得到两个新的黄烷化黄烷酮类化合物(2S)-2‘-甲氧基苦参素(1)和(-)-苦参素(2)，以及两个已知的黄烷基黄烷酮G(3)和马钱子酮A(4)，以及两个已知的异黄酮类化合物芒柄花素和L-苦参素。1和2的结构由旋光度和光谱证据确定，并与已知的化合物进行比较。化合物1-4对人髓系白血病HL-60细胞具有细胞毒活性。
Two new lavandulylated flavanones, (2S)-2'-methoxykurarinone (1) and (-)-kurarinone (2), were isolated from the root of Sophora flavescens, together with two known lavandulyl flavanones, sophoraflavanone G (3) and leachianone A (4), and two known isoflavonoids, formononetin and l-maakiain. The structures of 1 and 2 were determined on the basis of optical rotation and spectral evidence and by comparison with known compounds. Compounds 1-4 exhibited cytotoxic activity against human myeloid leukemia HL-60 cells.