Functions of Maternally-Derived Taurine in Fetal and Neonatal Brain Development
Functions of Maternally-Derived Taurine in Fetal and Neonatal Brain Development
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DOI：
10.1007/978-94-024-1079-2_2
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发表时间：
2017-01-01
期刊：
影响因子：
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通讯作者：
Tochitani, Shiro
中科院分区：
文献类型：
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作者：
Tochitani, Shiro
牛磺酸（2-氨基乙磺酸）是一种含硫的有机酸，具有多种生理功能，包括膜稳定、细胞体积调节、线粒体蛋白转位、抗氧化活性、神经保护和调节细胞内钙水平。牛磺酸还激活GABA（A）受体和甘氨酸受体。哺乳动物的胎儿和婴儿依赖于通过胎盘或母乳从母亲那里输送的牛磺酸。牛磺酸是一种连接母胎或母婴的分子，本文综述了牛磺酸在胎儿和脑发育中的功能及其作用机制。牛磺酸参与调节胎儿和新生儿发育期间神经祖细胞的增殖、新生神经元的迁移以及迁移后神经元的突触形成。在这篇综述中，我们还讨论了可能影响牛磺酸在神经发育中的功能作用的环境因素。
Taurine (2-aminoethanesulfonic acid) is a sulfur-containing organic acid, which has various physiological functions, including membrane stabilization, cell-volume regulation, mitochondrial protein translocation, anti-oxidative activity, neuroprotection against neurotoxicity and modulation of intracellular calcium levels. Taurine also activates GABA(A) receptors and glycine receptors. Mammalian fetuses and infants are dependent on taurine delivered from their mothers via either the placenta or their mother's milk. Taurine is a molecule that links mother-fetus or mother-infant bonding.This review describes the functions of taurine and the mechanisms of action of taurine in fetal and brain development. Taurine is involved in regulating the proliferation of neural progenitors, migration of newly-generated neurons, and the synapse formation of neurons after migration during fetal and neonatal development. In this review, we also discuss the environmental factors that might influence the functional roles of taurine in neural development.