Retinal putative glial alterations: implication for glaucoma care
Retinal putative glial alterations: implication for glaucoma care
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DOI：
10.1111/opo.12425
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发表时间：
2018-01-01
影响因子：
2.9
通讯作者：
Swanson, William H.
中科院分区：
文献类型：
--
作者：
Ashimatey, Bright S.;King, Brett J.;Swanson, William H.
目的青光眼患者视网膜神经胶质样改变（gliosis-like retinal alterations，Gliosis-like retinal alterations，ARAM）是一种常见的视网膜星形胶质细胞和苗勒细胞（retinal astrocytes and Muller cells，ARAM），在正常人中少见。我们研究了在光学相干断层扫描（OCT）面部图像上的视网膜异常与视网膜区域的存在、范围以及超反射视网膜改变的空间分布之间的关联，推测为ARAM.MethodsFindings的超反射结构，推测为ARAM，在35名年轻对照者、42名老年对照者和38名青光眼患者之间比较了中央视网膜24度OCT正面图像（用SPECTRALIS（（R））OCT获取）。假定ARAM定义为正面图像上除视网膜血管和视网膜神经纤维束以外的反射性结构。使用卡方检验比较年轻对照组与假定ARAM的老年对照组的比例，以研究衰老的影响，并比较假定ARAM的患者与年龄相似的老年对照组的比例，以研究疾病的影响。我们还调查了青光眼对视网膜面积的影响，当它存在时，我们使用协方差分析（ancova）来比较患者与对照组的视网膜面积与高反射率，调整年龄和眼轴长度的影响。年轻对照组、老年对照组和青光眼患者的年龄分别为26（3）、62（10）和69（8）岁。在年轻对照组、老年对照组和青光眼患者中，具有高反射结构的视网膜区域（假定为ARAM）的中位数（第25四分位数，第75四分位数）分别为0（0，0）、1（0，6）和11（0，43）平方度。调查老化效应的卡方检验发现（2）（1，N=77）=24.8，p
PurposeGliosis-like retinal alterations, presumed to be activated retinal astrocytes and Muller cells (ARAM), have been reported to occur frequently in patients with glaucoma but rarely in controls. We investigated the association between glaucomatous abnormality and the presence, the extent of retinal region, and the spatial distribution, of hyperreflective retinal alterations on optical coherence tomography (OCT) en-face images, presumed to be ARAM.MethodsFindings of hyperreflective structures, presumed to be ARAM, in the central retinal 24 degrees of OCT en-face images (acquired with the SPECTRALIS((R)) OCT) were compared between 35 younger controls, 42 older controls and 38 patients with glaucoma. Presumed ARAM was defined as reflective structures on the en-face images other than retinal vasculature and retinal nerve fibre bundles. Chi-square tests were used to compare the proportion of younger controls vs older controls with presumed ARAM to investigate the effect of ageing, and the proportion of patients vs age-similar older controls with presumed ARAM to investigate the effect of disease. We also investigated the effect of glaucoma on the retinal area with presumed ARAM when it was present; we used an analysis of covariance (ancova) to compare the retinal area with hyperreflectivity in patients vs controls, adjusting for the effects of age and axial length.ResultsThe mean (S.D.) age of the younger controls, older controls, and patients with glaucoma was 26 (3), 62 (10) and 69 (8) years, respectively. The median (25th quartile, 75th quartile) of the retinal region with the hyperreflective structures, presumed to be ARAM, was zero (0,0), 1 (0,6), and 11 (0,43) degrees square in the younger controls, older controls and patients with glaucoma respectively. The chi-square test investigating the effect of ageing found (2)(1, N=77)=24.8, p