Comparison of graded single intramuscular doses of morphine and pentobarbital in man
Comparison of graded single intramuscular doses of morphine and pentobarbital in man
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吗啡和戊巴比妥对人的分级单次肌肉注射剂量的比较
DOI：
10.1002/cpt1974156623
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发表时间：
1974
影响因子：
6.7
通讯作者：
Havelock F. Fraser
中科院分区：
文献类型：
--
作者：
W. Martin;W. O. Thompson;Havelock F. Fraser
对12名不耐受的麻醉剂成瘾者进行了分级单次肌肉注射硫酸吗啡（8、16和32 mg）和戊巴比妥钠（150、200和250 mg）及安慰剂的双盲给药。为了评估主观效应和相关体征的程度和时间过程，由受试者和观察者完成“单次和长期剂量”阿片类药物问卷。利用瞳孔照片和眼球后转性眼震持续时间，同时进行药物作用的客观测量。总的来说，调查问卷显示了吗啡和戊巴比妥的明确和不同的症状和体征。客观测量也不同。吗啡诱导瞳孔直径呈剂量相关性减小，抓挠、松弛、滑行、多话和结膜充血体征增加，并导致松弛、多话和胃翻转。戊巴比妥诱导了旋转后眼球震颤持续时间的剂量相关性增加，并导致嗜睡和醉酒。两种药物都能引起欣快症。
Graded single intramuscular doses of morphine sulfate (8, 16, and 32 mg) and pentobarbital sodium (150, 200, and 250 mg) and a placebo were administered double blind to 12 nontolerant narcotic addicts. To assess the the magnitude and time course of subiective effects and associated signs, “single and chronic dose” opiate questionnaires were completed by subjects and observers. Objective measurements of drug effect were concurrently made, using photographs of the pupils and the duration of postrotational nystagmus. Overall, the questionnaires showed definite and different constellations of symptoms and signs for morphine and pentobarbital. Objective measurements were also different. Morphine induced a dose‐related decrease in pupillary diameter and an increase in the signs scratching, relaxed, coasting, talkativeness, and conjunctival injection and caused relaxation, talkativeness, and turning of the stomach. Pentobarbital induced a dose‐related increase in the duration of postrotational nystagmus and caused sleepiness and drunkenness. Both drugs induced euphoria.