Cooperative catalysis with chiral Bronsted acid-Rh2(OAC)4:: Highly enantioselective three-component reactions of diazo compounds with alcohols and imines
Cooperative catalysis with chiral Bronsted acid-Rh2(OAC)4:: Highly enantioselective three-component reactions of diazo compounds with alcohols and imines
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DOI：
10.1021/ja801755z
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发表时间：
2008-06-25
影响因子：
15
通讯作者：
Gong, Liu-Zhu
中科院分区：
文献类型：
--
作者：
Hu, Wenhao;Xu, Xinfang;Gong, Liu-Zhu
在铑络合物和手性布朗斯台德酸的协同催化下，重氮化合物和醇与亚胺的不对称三组分反应提供了一种通用且有效的方法，以高产率和优异的立体选择性制备β-氨基-α-羟基酸衍生物。
An asymmetric three-component reaction of diazo compounds and alcohols with imines catalyzed cooperatively by a rhodium complex and a chiral Bronsted acid provides a general and efficient entry to beta-amino-a-hydroxyl acid derivatives in high yields with excellent stereoselectivities.