Shape Memory Properties and Enzymatic Degradability of Poly(ε-caprolactone)-Based Polyurethane Urea Containing Phenylalanine-Derived Chain Extender
Shape Memory Properties and Enzymatic Degradability of Poly(ε-caprolactone)-Based Polyurethane Urea Containing Phenylalanine-Derived Chain Extender
复制标题
含苯丙氨酸衍生扩链剂聚(ε-己内酯)基聚氨酯脲的形状记忆性能和酶降解性
DOI：
10.1002/mabi.201800054
复制
发表时间：
2018-06-01
影响因子：
4.6
通讯作者：
Tan, Hong
中科院分区：
文献类型：
--
作者：
Wang, Rong;Zhang, Fanjun;Tan, Hong
可生物降解的形状记忆聚合物是一种很有前途的微创外科手术材料。本文合成了一系列含有新型苯丙氨酸扩链剂的线性可生物降解的形状记忆聚己内酯（PCL）基聚氨酯脲（PUU）。苯丙氨酸衍生的扩链剂，苯丙氨酸-己二胺-苯丙氨酸（PHP），含有两个胰凝乳蛋白酶裂解位点以增强PUU的酶促降解。PUU的降解速率、结晶度和机械性能由PHP的含量定制。同时，半结晶PCL不仅可水解降解，而且对形状记忆至关重要。由于硬链段中的强相互作用可实现永久交联和PCL的结晶-熔融转变可切换暂时形状，因此PUU在体温下具有良好的形状记忆能力。PUU作为植入支架具有很大的应用潜力。
Biodegradable shape memory polymers are promising biomaterials for minimally invasive surgical procedures. Herein, a series of linear biodegradable shape memory poly(epsilon-caprolactone) (PCL)-based polyurethane ureas (PUUs) containing a novel phenylalanine-derived chain extender is synthesized. The phenylalanine-derived chain extender, phenylalanine-hexamethylenediamine-phenylalanine (PHP), contains two chymotrypsin cleaving sites to enhance the enzymatic degradation of PUUs. The degradation rate, the crystallinity, and mechanical properties of PUUs are tailored by the content of PHP. Meanwhile, semicrystalline PCL is not only hydrolytically degradable but also vital for shape memory. Good shape memory ability under body temperature is achieved for PUUs due to the strong interactions in hard segments for permanent crosslinking and the crystallization-melt transition of PCL to switch temporary shape. The PUUs would have a great potential in application as implanting stent.