Invasive Group A Streptococcal Infections in Sweden in 1994 and 1995: Epidemiology and Clinical Spectrum
Invasive Group A Streptococcal Infections in Sweden in 1994 and 1995: Epidemiology and Clinical Spectrum
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1994 年和 1995 年瑞典侵袭性 A 组链球菌感染：流行病学和临床谱
DOI：
10.1080/003655400459504
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发表时间：
2000
影响因子：
--
通讯作者：
J. Giesecke
中科院分区：
文献类型：
--
作者：
N. Svensson;Sven Öberg;B. Henriques;S. Holm;G. Källenius;V. Romanus;J. Giesecke
在1994-1995年期间，在瑞典进行了一项侵袭性A组链球菌（GAS）感染的全国性研究。要求所有瑞典微生物实验室报告来自正常无菌场所的GAS分离株。在研究期间，还要求他们将分离株送去进行T分型。病历被送到负责每一位病人的医生手中。记录发病率、血清型、临床表现、症状和转归。获得了556例GAS菌血症患者中468例的临床数据。致死率为16%，但在113例发生链球菌中毒性休克综合征（STSS）的患者中，致死率要高得多（37%）。在研究期间，T1血清型链球菌占主导地位，并与侵袭性GAS感染的增加有关。它们也增加了引起STSS的风险。伴有STSS的侵袭性链球菌病通常有未知的原发灶或与软组织感染有关。与STSS无关的侵袭性链球菌病最常以皮肤感染为入口或不明病灶。
A nationwide study of invasive group A streptococcal (GAS) infections in Sweden during 1994-1995 was carried out. All Swedish microbiological laboratories were asked to report isolates of GAS from normally sterile sites. During the study period they were also asked to send their isolates for T typing. Questionnaires were sent to the physicians in charge of each patient. The incidence, serotype, clinical presentation, symptoms and outcome were recorded. Clinical data were obtained for 468 of 556 patients with GAS bacteraemia. The lethality rate was 16%, but was much higher (37%) in the 113 patients who developed streptococcal toxic shock syndrome (STSS). Streptococci of serotype T1 dominated during the study period and were linked to the increase in invasive GAS infections. They also carried an increased risk of causing STSS. Invasive streptococcal disease with STSS most often has an unknown primary focus or is associated with soft tissue infections. Invasive streptococcal disease not associated with STSS most often has a skin infection as portal of entry or else an unknown focus.
表达热原性外毒素 A（猩红热毒素）等位基因变体的两个高致病性化脓性链球菌克隆的地理和时间分布及分子特征。
DOI：
10.1093/infdis/167.2.337
发表时间：
1993
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Musser,JM;Kapur,V;Kanjilal,S;Shah,U;Musher,DM;Barg,NL;Johnston,KH;Schlievert,PM;Henrichsen,J;Gerlach,D
通讯作者：
Gerlach,D