NAVIGATED DIFFUSION IMAGING OF NORMAL AND ISCHEMIC HUMAN BRAIN
NAVIGATED DIFFUSION IMAGING OF NORMAL AND ISCHEMIC HUMAN BRAIN
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DOI：
10.1002/mrm.1910330518
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发表时间：
1995-05-01
影响因子：
3.3
通讯作者：
MOSELEY, ME
中科院分区：
文献类型：
--
作者：
DECRESPIGNY, AJ;MARKS, MP;MOSELEY, ME
扩散加权MR成像的临床应用的主要障碍是由患者运动引起的严重图像退化。补偿运动效应的一种方式是使用“导航回波”相位校正方案。在这项工作中，引入了对该技术的修改，其中在频域中执行相位校正步骤（即，在读出傅立叶变换之后）。这显著提高了导航回波方法的鲁棒性，并且当与心脏门控结合时，允许在标准临床扫描仪硬件上常规获得诊断质量的脑部扩散加权图像。在体模研究和23例人类（3名正常志愿者和20名患者）中对该技术进行了评价。弥散各向异性和表观弥散系数图是从图像数据中生成的，显示急性卒中病变的表观弥散降低，在某些情况下，慢性卒中病变的表观弥散增加。
The principal barrier to clinical application of diffusion-weighted MR imaging is the severe image degradation caused by patient motion, One way to compensate for motion effects is the use of a ''navigator echo'' phase correction scheme, In this work, a modification of this technique is introduced, in which the phase correction step is performed in the frequency domain (i.e., after the readout Fourier transform). This significantly improves the robustness of the navigator echo approach and, when combined with cardiac gating, allows diagnostic quality diffusion-weighted images of the brain to be routinely obtained on standard clinical scanner hardware, The technique was evaluated in phantom studies and in 23 humans (3 normal volunteers and 20 patients). Diffusion anisotropy and apparent diffusion coefficient maps were generated from the image data and showed decreased apparent diffusion in acute stroke lesions and, in several cases, increased apparent diffusion in chronic stroke lesions.