Activation of a wide-spread network of inhibitory neurons in barrel cortex.
Activation of a wide-spread network of inhibitory neurons in barrel cortex.
复制标题
桶状皮质中广泛分布的抑制性神经元网络的激活。
DOI：
10.1080/08990229771141
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Woolsey,TA
中科院分区：
文献类型：
--
作者：
McCasland,JS;Hibbard,LS;Rhoades,RW;Woolsey,TA
一对一的对应关系的胡须到桶在第四层的啮齿动物体感皮层可以证明一个精确的匹配之间的列的重2-脱氧葡萄糖（2DG）标签在第四层桶和其他层，对应于刺激的胡须。虽然存在外周到中枢映射的特异性，但是由桶限定的须柱内的电路或桶限定的须柱之间的相互作用产生的整合和/或调制的程度尚不清楚。刺激选定的晶须后，在整个桶场的层IV-V边界的大细胞大量标记的2-脱氧葡萄糖（2DG）在高分辨率。这些细胞中的许多都在受刺激的胡须的桶柱之外。此外，标记的细胞数量与激活的桶柱数量没有直接关系。这些神经元在2DG注射前麻醉的动物中未被标记，并且在嗜睡动物的桶场中未被大量标记。大多数重度标记的神经元免疫标记为谷氨酸脱羧酶（GAD），并推测是抑制性的，而少数标记的神经元，推测是兴奋性的，免疫标记为谷氨酸（Glu）。在其他皮质区域也发现了类似的大量2DG标记的神经元。这些相对较少的神经元异常活跃，可能调节大脑皮层的整合功能。
The one-to-one correspondence of whiskers to barrels in layer IV of rodent somatosensory cortex can be demonstrated by a precise match between columns of heavy 2-deoxyglucose (2DG) label in layer IV barrels and other layers which correspond to stimulated whiskers. While there is specificity of peripheral-to-central mapping, the extent to which integration and/or modulation are generated by circuitry within or interactions between the barrel-defined whisker columns is not clear. Following stimulation of selected whiskers, large cells at the layer IV-V boundary throughout the barrel field are heavily labeled by 2-deoxyglucose (2DG) at high resolution. Many of these cells are outside the barrel columns of the stimulated whiskers. Further, the number of cells labeled is not directly related to the number of activated barrel columns. These neurons are not labeled in animals anesthetized before 2DG injection and are not as heavily labeled in barrel fields of somnolent animals. Most of the heavily labeled neurons immunolabel for glutamate decarboxylase (GAD) and are presumed to be inhibitory, while a smaller number of labeled neurons, presumed to be excitatory, immunolabel for glutamate (Glu). Similar populations of large, heavily 2DG-labeled neurons are found in other cortical areas. These relatively few neurons are exceptionally active and may modulate integrative functions of cerebral cortex.