High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis
High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis
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DOI：
10.1212/wnl.0000000000008081
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发表时间：
2019-10-22
期刊：
影响因子：
9.9
通讯作者：
Bateman, Randall J.
中科院分区：
文献类型：
--
作者：
Schindler, Suzanne E.;Bollinger, James G.;Bateman, Randall J.
目的以淀粉样蛋白PET或CSF p-tau181/A β 42为参比标准，检测血浆β -淀粉样蛋白（A β）42/A β 40是否能准确诊断脑淀粉样变性。方法采用免疫沉淀和液相色谱-质谱联用技术，对158例在淀粉样蛋白PET扫描后18个月内收集的大多数认知正常个体的血浆和脑脊液样本中的A β 42/A β 40进行了测定。结果血浆A β 42/A β 40与淀粉样蛋白PET状态（受试者曲线下工作特征面积[AUC] 0.88, 95%可信区间[CI] 0.82 ~ 0.93）和CSF p-tau181/A β 42 （AUC 0.85, 95%可信区间[CI] 0.79 ~ 0.92）高度对应。血浆A β 42/A β 40、年龄和APOE epsilon 4状态的组合与淀粉样蛋白PET的相关性非常高（AUC 0.94, 95% CI 0.90-0.97）。基线时淀粉样蛋白PET扫描呈阴性，血浆a β 42/ a β 40呈阳性(
ObjectiveWe examined whether plasma beta-amyloid (A beta)42/A beta 40, as measured by a high-precision assay, accurately diagnosed brain amyloidosis using amyloid PET or CSF p-tau181/A beta 42 as reference standards.MethodsUsing an immunoprecipitation and liquid chromatography-mass spectrometry assay, we measured A beta 42/A beta 40 in plasma and CSF samples from 158 mostly cognitively normal individuals that were collected within 18 months of an amyloid PET scan.ResultsPlasma A beta 42/A beta 40 had a high correspondence with amyloid PET status (receiver operating characteristic area under the curve [AUC] 0.88, 95% confidence interval [CI] 0.82-0.93) and CSF p-tau181/A beta 42 (AUC 0.85, 95% CI 0.79-0.92). The combination of plasma A beta 42/A beta 40, age, and APOE epsilon 4 status had a very high correspondence with amyloid PET (AUC 0.94, 95% CI 0.90-0.97). Individuals with a negative amyloid PET scan at baseline and a positive plasma A beta 42/A beta 40 (