The gonadal hormone regulates the plasma lactate levels in type 2 diabetes treated with and without metformin.
The gonadal hormone regulates the plasma lactate levels in type 2 diabetes treated with and without metformin.
复制标题
性腺激素可调节使用或不使用二甲双胍治疗的 2 型糖尿病患者的血浆乳酸水平。
DOI：
10.1089/dia.2011.0275
复制
发表时间：
2012
影响因子：
5.4
通讯作者：
W. Jia
中科院分区：
文献类型：
--
作者：
Ying;Fang Liu;Qing Li;Jun;T. Zheng;Feng;Hui‐juan Lu;W. Jia
OBJECTIVE
Our previous study showed there was a gender difference in plasma lactate concentrations in subjects with type 2 diabetes. This study investigated the effect of sex hormone levels on plasma lactic acid (LA) levels in type 2 diabetes with and without metformin therapy.
SUBJECTS AND METHODS
Fasting whole blood specimens of 392 type 2 diabetes patients treated with metformin (n=199) or not (n=193) were collected. LA was measured with an enzyme-electrode assay. Levels of sex hormones, including testosterone (T) and estradiol (E(2)), were measured with a chemiluminescence microparticle immunoassay. Spearman's or Pearson's correlation and logistic regression analysis were performed for the factors associated with LA.
RESULTS
The LA level in the metformin group was significantly higher than that in the non-metformin group (1.26±0.43 vs. 1.14±0.49 mmol/L, P<0.001), and LA levels of females were significantly higher than those of males (P<0.001). LA concentrations were positively correlated with E(2) level but negatively correlated with metformin and T levels (P<0.01). The logistic regression analysis showed that gender, creatinine, E(2), metformin, and T were independent factors influencing lactate levels. Analysis of subgroups demonstrated that the LA concentrations increased with the elevation of E(2) level (P<0.05) but decreased with the rising of T level (P<0.05).
CONCLUSIONS
Sex hormones play an important role on regulating plasma lactate levels in diabetes patients treated with metformin. E(2) up-regulates but T tend to down-regulate lactate levels.
