Post-breast cancer radiotherapy bronchiolitis obliterans organizing pneumonia
Post-breast cancer radiotherapy bronchiolitis obliterans organizing pneumonia
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DOI：
10.1586/ers.13.1
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发表时间：
2013-04-01
影响因子：
3.9
通讯作者：
Epler, Gary R.
中科院分区：
文献类型：
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作者：
Epler, Gary R.
接受乳腺癌放射治疗的女性中，放射治疗后闭塞性细支气管炎机化性肺炎的发生率可能高达 2.3%。咳嗽和发烧是常见症状，其中四分之一的女性没有症状。潜伏期通常为治疗完成后 6 个月内，但也可能长达 1 年。肺功能正常或显示肺活量和弥散能力轻微下降。胸部计算机断层扫描研究显示，辐射野内外有毛玻璃样混浊，伴有空气支气管征，周围常有三角形浸润。治疗包括密切监测无症状或症状轻微的女性，以及对有症状和广泛闭塞性细支气管炎机化性肺炎的女性进行短期皮质类固醇治疗。预后良好；目前尚无死亡报告。
Post-radiotherapy bronchiolitis obliterans organizing pneumonia may occur in as many as 2.3% of women receiving radiation therapy for breast cancer. Cough and fever are common symptoms, and a quarter of these women have no symptoms. Latency period is usually within 6 months after completion of therapy but may be as long as 1 year. Pulmonary function is normal or will show slight decreases in vital capacity and diffusing capacity. Chest computed tomography studies show ground-glass opacities with air bronchograms within and outside the radiation field, and there are often peripheral triangular-shaped infiltrates. Management consists of close monitoring of women who have no symptoms or minimal symptoms, and a short-course of corticosteroid therapy for women who have symptoms and extensive bronchiolitis obliterans organizing pneumonia. The prognosis is excellent; there have been no deaths reported.