Particle deposition in a multiple-path model of the human lung
Particle deposition in a multiple-path model of the human lung
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DOI：
10.1080/02786820151092478
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发表时间：
2001-04-01
影响因子：
5.2
通讯作者：
Bergmann, R
中科院分区：
文献类型：
--
作者：
Asgharian, B;Hofman, W;Bergmann, R
预测暴露于空气颗粒物后人体肺部的颗粒沉积量是评估与暴露于空气污染物相关风险的第一步。为了准确预测肺中的沉积，需要真实的沉积模型，但主要的限制是肺几何形状可以被准确重建的程度。人肺的整个气道树的形态测量数据不可用。到目前为止，理想的肺结构已被用于沉积计算。在这项研究中，根据Raabe等人（1976）的形态测量，为人类肺的传导气道生成了10个统计肺结构。将对称的二分分支肺泡气道结构连接到每个肺结构的传导气道树的末端。肺泡区域的总体积在肺几何形状之间是相同的。使用以前开发的数学方案（Anjilvel和Asgharian 1995年），区域，Lobar和每代沉积的粒子计算在这些几何形状。将结果与使用典型路径和五叶对称肺几何模型的沉积预测进行比较。所有三种肺模型显示出非常相似的区域和逐代沉积结果。发现肺叶沉积强烈依赖于所使用的肺结构的详细形态测量。
Predicting the amount of particle deposition in the human lung following exposure to airborne particulate matter is the first step toward evaluating risks associated with exposure to airborne pollutants. Realistic deposition models are needed for accurate predictions of deposition in the lung, but a major limitation is the degree to which the lung geometry can be accurately reconstructed. Morphometric data for the entire airway tree of the human lung are not available. So far, idealistic lung structures have been used for deposition calculations. In this study, 10 statistical lung structures based on morphometric measurements of Raabe et al. (1976) were generated for the conducting airways of the human lung. A symmetric, dichotomous branching alveolar airway structure was attached to the end of the conducting airway tree of each lung structure. The total volume of the alveolar region was the same among the lung geometries. Using a mathematical scheme developed previously (Anjilvel and Asgharian 1995), regional, Lobar, and per-generation depositions of particles were calculated in these geometries. The results were compared to deposition predictions using typical-path and five-lobe symmetric lung geometry models. All three lung models showed very similar regional and generation-by-generation deposition results. Lobar deposition was found to strongly depend on the detailed morphometry of the lung structure that was used.