Post-exposure vaccination with the vaccine candidate Bacillus Calmette-Guerin ΔureC::hly induces superior protection in a mouse model of subclinical tuberculosis
Post-exposure vaccination with the vaccine candidate Bacillus Calmette-Guerin ΔureC::hly induces superior protection in a mouse model of subclinical tuberculosis
复制标题
DOI：
10.1016/j.micinf.2016.03.005
复制
发表时间：
2016-05-01
影响因子：
5.8
通讯作者：
Kaufmann, Stefan H. E.
中科院分区：
文献类型：
--
作者：
Gengenbacher, Martin;Kaiser, Peggy;Kaufmann, Stefan H. E.
结核疫苗BCG Delta ureC::hly是处于II期临床开发阶段的最先进的卡介苗替代候选药物。本研究评估了该构建体在感染结核分枝杆菌前和暴露后分别作为同源启动-增强疫苗和暴露后疫苗给予小鼠的保护能力。多次免疫并没有提高卡介苗δ ureC::hly优于卡介苗的保护作用。与卡介苗相比，接种卡介苗δ ureC::hly对亚临床结核动物有更好的保护作用。我们的研究结果建议进一步考虑使用BCG Delta ureC::hly作为暴露后疫苗。(C) 2016年巴斯德研究所。Elsevier Masson SAS出版。版权所有。
The tuberculosis vaccine BCG Delta ureC::hly is the most advanced BCG replacement candidate in phase II clinical development. Here we assess the protective capacity of the construct administered to mice as homologous prime-boost vaccine prior Mycobacterium tuberculosis infection and as post-exposure vaccine. Multiple immunization did not improve the superior protection of BCG Delta ureC::hly over BCG. Animals with sub-clinical tuberculosis were better protected when vaccinated with BCG Delta ureC::hly as compared to BCG. Our findings suggest further consideration of BCG Delta ureC::hly as post-exposure vaccine. (C) 2016 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.