Holistic Rehabilitation: Biological Embedding of Social Adversity and Its Health Implications.
Holistic Rehabilitation: Biological Embedding of Social Adversity and Its Health Implications.
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整体康复：社会逆境的生物嵌入及其健康影响。
DOI：
10.1093/ptj/pzab245
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发表时间：
2022
期刊：
影响因子：
3.2
通讯作者：
Snyder-Mackler,Lynn
中科院分区：
文献类型：
--
作者：
Snyder-Mackler,Noah;Snyder-Mackler,Lynn
人类健康受到过去和现在的生活经历的影响。因此，我们一生中遇到的环境决定了我们如何应对新的挑战，如何保持健康的免疫系统，甚至如何应对治疗和康复。在生命的早期和整个成年期，社会经历——比如接触各种形式的逆境——会改变我们身体细胞的功能，对人类的健康、疾病和治疗产生深远的影响。这一观点强调了来自越来越多的关于健康的社会决定因素的文献的研究，重点是在生命早期和成年期经历的社会逆境，如社会孤立、歧视或社会地位低下，以及它们如何以不同的方式影响健康。通过关注最近对人类和社会性非人类动物的观察性研究，本文详细介绍了社会逆境如何在分子水平上成为我们细胞中的生物学嵌入。鉴于人类是社会性动物，社会逆境会对我们的健康产生负面影响也就不足为奇了，实验动物研究已经帮助我们揭示了社会逆境与健康结果之间联系的一些因果机制途径。这些分子后果可能产生深远的影响，并且与我们对健康的社会决定因素的日益增长的知识相结合，应该为我们如何处理治疗和康复提供信息。
Human health is affected by lived experiences, both past and present. The environments we encounter throughout our lives, therefore, shape how we respond to new challenges, how we maintain a healthy immune system, and even how we respond to treatment and rehabilitation. Early in life and throughout adulthood, social experiences—such as exposure to various forms of adversity—can alter how cells in our body function, with far-reaching consequences for human health, disease, and treatment. This Perspective highlights studies from an ever-growing body of literature on the social determinants of health, with a focus on exposure to social adversities, such as social isolation, discrimination, or low social status, experienced both early in life and adulthood and how they variably impact health. By focusing on recent observational studies in humans and experimental studies on social nonhuman animals, this article details how social adversity can become biologically embedded in our cells at the molecular level. Given that humans are social animals, it is no surprise that social adversity can negatively impact our health, and experimental animal studies have helped us to uncover some of the causal mechanistic pathways underlying the link between social adversity and health outcomes. These molecular consequences can have far-reaching implications and, when combined with our growing knowledge on the social determinants of health, should inform how we approach treatment and rehabilitation.