In vitro study of flow regulation for pulmonary insufficiency.
In vitro study of flow regulation for pulmonary insufficiency.
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肺功能不全血流调节的体外研究。
DOI：
10.1115/1.2540892
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
McQuinn,T
中科院分区：
文献类型：
--
作者：
Camp,TA;Stewart,KC;Figliola,RS;McQuinn,T
鉴于右心循环对轻度反流和梯度的耐受性，我们研究了使用不动装置调节肺循环的潜力。此外，我们记录了两个机械阀的流动性能。在肺模拟循环系统中，在正常人体肺血管阻力（PVR）范围内对静止二极管、喷嘴、机械双叶瓣膜和倾斜圆盘瓣膜进行了测试。对于机械阀，反流分数（RFs）和跨瓣压力梯度是PVR的弱函数。在正常PVR的低端，双叶瓣和倾斜瓣瓣颤振，不能完全关闭。尽管有这种异常，但两个瓣膜的反流部分没有明显变化。RF和跨瓣梯度的测量值从4%到7%不等，在所有测试中均为0%。二极管阀能够以温和的反流分数和小梯度调节流量，但其值高于测试的任何机械阀。在试验中，返流分数范围从2%到17%，从PVR值扩展到，并伴随梯度增加到。在PVR范围内，喷嘴的反流分数从2%增加到23%，梯度增加到。结果表明：(1)机械瓣膜在正常生理心排血量和PVR值下可控制返流，但在正常PVR值下仍不能关闭，并表现出小叶扑动；(2)使用不动的肺动脉瓣装置将肺循环调节到可容忍的水平是可能的。
Given the tolerance of the right heart circulation to mild regurgitation and gradient, we study the potential of using motionless devices to regulate the pulmonary circulation. In addition, we document the flow performance of two mechanical valves. A motionless diode, a nozzle, a mechanical bileaflet valve, and a tilting disk valve were tested in a pulmonary mock circulatory system over the normal human range of pulmonary vascular resistance (PVR). For the mechanical valves, regurgitant fractions (RFs) and transvalvular pressure gradients were found to be weak functions of PVR. On the low end of normal PVR, the bileaflet and tilting disk valves fluttered and would not fully close. Despite this anomaly, the regurgitant fraction of either valve did not change significantly. The values for RF and transvalvular gradient measured varied from 4 to 7% and, respectively, atfor all tests. The diode valve was able to regulate flow with mild regurgitant fraction and trivial gradient but with values higher than either mechanical valve tested. Regurgitant fraction ranged from 2 to 17% in tests extending from PVR values ofatand with concomitant increases in gradient up to. The regurgitant fraction for the nozzle increased from 2 to 23% over the range of PVR with gradients increasing to. The significant findings were: (1) the mechanical valves controlled regurgitation at normal physiological cardiac output and PVR even though they failed to close at some normal values of PVR and showed leaflet flutter; and (2) it may be possible to regulate the pulmonary circulation to tolerable levels using a motionless pulmonary valve device.