Nanoparticles for cancer gene therapy: Recent advances, challenges, and strategies.
Nanoparticles for cancer gene therapy: Recent advances, challenges, and strategies.
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DOI：
10.1016/j.phrs.2016.10.016
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发表时间：
2016-12
影响因子：
9.3
通讯作者：
Kui Wang;Forrest M. Kievit;Miqin Zhang
中科院分区：
文献类型：
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作者：
Kui Wang;Forrest M. Kievit;Miqin Zhang
与常规治疗相比，基因治疗为癌症治疗提供了多种优势，包括高效力和特异性、低脱靶毒性以及同时靶向癌症肿瘤发生、复发和耐药性的多个基因的递送。在过去的几十年里，基因治疗取得了显著的进展，现在有望成为癌症的一线治疗方法。在众多的基因传递系统中，纳米粒子因其具有低毒性、可控性好、传递效率高、多功能等优点而备受关注。本文综述了基因治疗和基因递送技术，并强调了最近的进展，挑战和见解的设计和利用纳米粒子在基因治疗癌症。
Compared to conventional treatments, gene therapy offers a variety of advantages for cancer treatment including high potency and specificity, low off-target toxicity, and delivery of multiple genes that concurrently target cancer tumorigenesis, recurrence, and drug resistance. In the past decades, gene therapy has undergone remarkable progress, and is now poised to become a first line therapy for cancer. Among various gene delivery systems, nanoparticles have attracted much attention because of their desirable characteristics including low toxicity profiles, well-controlled and high gene delivery efficiency, and multi-functionalities. This review provides an overview on gene therapeutics and gene delivery technologies, and highlight recent advances, challenges and insights into the design and the utility of nanoparticles in gene therapy for cancer treatment.