A revised nomenclature for the human and rodent α-tubulin gene family
A revised nomenclature for the human and rodent α-tubulin gene family
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DOI：
10.1016/j.ygeno.2007.04.008
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发表时间：
2007-08-01
期刊：
影响因子：
4.4
通讯作者：
Lovering, Ruth C.
中科院分区：
文献类型：
--
作者：
Khodiyar, Varsha K.;Maltais, Lois J.;Lovering, Ruth C.
微管蛋白是微管的重要组成部分，在许多物种中也是一个多基因家族。由于不完整的基因组构建和该家族成员之间的高度序列相似性，该基因家族的基于直系同源的命名法以前很难分配。使用目前的基因组构建，人类，小鼠和大鼠α-微管蛋白基因的序列分析已经能够产生更新的命名法。这一修订后的命名法为哺乳动物物种中这些基因的讨论提供了统一的语言;它已得到这三个物种的基因命名委员会的批准，并得到了该领域研究人员的支持。(c)2007年爱思唯尔公司All rights reserved.
\An essential component of micrombules, alpha-tubulin is also a multigene family in many species. An orthology-based nomenclature for this gene family has previously been difficult to assign due to incomplete genome builds and the high degree of sequence similarity between members of this family. Using the current genome builds, sequence analysis of human, mouse, and rat alpha-tubulin genes has enabled an updated nomenclature to be generated. This revised nomenclature provides a unified language for the discussion of these genes in mammalian species; it has been approved by the gene nomenclature committees of the three species and is supported by researchers in the field. (c) 2007 Elsevier Inc. All rights reserved.