Mindfulness-based cognitive therapy (MBCT), cognitive style, and the temporal dynamics of frontal EEG alpha asymmetry in recurrently depressed patients
Mindfulness-based cognitive therapy (MBCT), cognitive style, and the temporal dynamics of frontal EEG alpha asymmetry in recurrently depressed patients
复制标题
DOI：
10.1016/j.biopsycho.2011.08.008
复制
发表时间：
2011-12-01
影响因子：
2.6
通讯作者：
Kotchoubey, Boris
中科院分区：
文献类型：
--
作者：
Keune, Philipp M.;Bostanov, Vladimir;Kotchoubey, Boris
正念认知疗法（MBCT）是一种以冥想为基础的维持疗法，可降低重度抑郁症（MDD）患者的复发风险。然而，只有少数研究调查了这种保护作用背后的心理生理机制。我们研究了MBCT对反刍和正念特质的影响，作为整体认知风格的指标，以及对缓解期复发抑郁症患者（n = 78）残留抑郁症状的影响。另外，对静息状态脑电图（EEG）的α -不对称性进行了评估。研究发现，α -不对称可以预测情感风格，表明右半球前皮层相对活动更强的模式可能是患重度抑郁症易感性的特征标志。与之前的研究结果一致，MBCT后残余抑郁症状和特质反刍减少，而特质正念增加，而等候名单对照组没有发生这种变化。另一方面，alpha不对称的平均值不受训练的影响，并且在整个样本中系统地转向表明右半球前皮层相对更强的模式。这些发现为MBCT的保护作用提供了进一步的支持。然而，在复发率极高的患者中，这种影响并没有在神经生理水平上表现出来，即α不对称，在那里观察到一种转移，推测表明易感性增加。(C) 2011 Elsevier B.V.版权所有
Mindfulness-based cognitive therapy (MBCT), a meditation-based maintenance therapy, reduces the relapse risk in individuals suffering from major depressive disorder (MDD). However, only a few studies investigated the psychophysiological mechanisms underlying this protective effect. We examined effects of MBCT on trait rumination and mindfulness, as indicators of global cognitive style, as well as on residual depressive symptoms in a group of recurrently depressed patients (n = 78) in remission. Additionally, alpha asymmetry in resting-state electroencephalogram (EEG) was assessed. Alpha asymmetry has been found to be predictive of affective style and a pattern indicative of stronger relative right-hemispheric anterior cortical activity may represent a trait marker for the vulnerability to develop MDD.In line with previous findings, residual depressive symptoms and trait rumination decreased, whereas trait mindfulness increased following MBCT, while no such changes took place in a wait-list control group. Mean values of alpha asymmetry, on the other hand, remained unaffected by training, and shifted systematically toward a pattern indicative of stronger relative right-hemispheric anterior cortical activity in the whole sample. These findings provide further support for the protective effect of MBCT. In the examined patients who were at an extremely high risk for relapse, however, this effect did not manifest itself on a neurophysiological level in terms of alpha asymmetry, where a shift, putatively indicative of increased vulnerability, was observed. (C) 2011 Elsevier B.V. All rights reserved.