HEPATIC-UPTAKE OF ALBUMIN-BOUND SUBSTANCES - ALBUMIN RECEPTOR CONCEPT
HEPATIC-UPTAKE OF ALBUMIN-BOUND SUBSTANCES - ALBUMIN RECEPTOR CONCEPT
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DOI：
10.1152/ajpgi.1983.245.1.g13
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发表时间：
1983-01-01
影响因子：
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通讯作者：
GOLLAN, JL
中科院分区：
文献类型：
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作者：
OCKNER, RK;WEISIGER, RA;GOLLAN, JL
长链脂肪酸和其他与血浆中白蛋白紧密结合的物质的单程肝脏摄取令人惊讶地有效。最近对这些物质中的几种的动力学研究表明，摄取主要是通过白蛋白-配体复合物与[大鼠]肝细胞表面的直接相互作用介导的，而不是像通常认为的那样通过小部分未结合的配体介导的。此外，已发现125 I-白蛋白与分离的肝细胞、脂肪细胞和红细胞特异性地、饱和地和可逆地结合。虽然这些结合位点的性质和可能的调节仍有待充分阐明，推定的白蛋白受体可能在白蛋白和细胞之间的许多类内源性和外源性物质的双向转移中发挥重要作用。
The single-pass hepatic uptake of long-chain fatty acids and other substances bound tightly to albumin in plasma is surprisingly efficient. Recent kinetic studies for several of these substances suggest that uptake is mediated primarily by direct interaction of the albumin-ligand complex with the [rat] hepatocyte surface rather than by the small fraction of unbound ligand, as has been generally believed. Furthermore, 125I-albumin has been found to bind specifically, saturably and reversibly to isolated hepatocytes, adipocytes and erythrocytes. Although the nature and possible regulation of these binding sites remain to be fully elucidated, the putative albumin receptor may play an important role in the bidirectional transfer of many classes of endogenous and exogenous substances between albumin and cells.