Depressive symptoms, psychiatric medication use, and risk of type 2 diabetes: results from the Health and Retirement Study.
Depressive symptoms, psychiatric medication use, and risk of type 2 diabetes: results from the Health and Retirement Study.
复制标题
DOI：
10.1016/j.genhosppsych.2015.05.008
复制
发表时间：
2015-09
影响因子：
7
通讯作者：
Mezuk B
中科院分区：
文献类型：
--
作者：
Ratliff S;Mezuk B
This prospective study investigates the relationships between depressive symptoms, psychiatric medication use, and their interaction on risk of developing type 2 diabetes. Data come from the 1998 – 2010 waves of the Health and Retirement Study, a U.S. nationally-representative cohort of adults aged 51 and older. Analysis is restricted to participants <65 who did not have diabetes in 1998 (N=8,704). Depressive symptoms were assessed using the 8-item Center for Epidemiologic Studies–Depression scale. Risk of diabetes over the 12-year follow-up period was assessed using Cox proportional hazard models with time-varying covariates. After adjusting for covariates, both depressive symptoms (hazard ratio [HR]: 1.06, 95% Confidence Interval [CI]: 1.02 – 1.09) and psychiatric medication use (HR: 1.57, 95% CI: 1.25 – 1.96) were associated with development of diabetes. The interaction between depressive symptoms and medication use was significant (beta = −0.240, p = .049), indicating that the association between elevated depressive symptoms and diabetes was higher among respondents not taking medications. The associations between depressive symptoms and medication use were also attenuated by increasing BMI. Findings highlight the complex relationship between depressive symptoms and psychiatric medications on diabetes risk, and the need for a nuanced understanding of these factors.
