A new 68Ge/68Ga generator system using an organic polymer containing N-methylglucamine groups as adsorbent for 68Ge
A new 68Ge/68Ga generator system using an organic polymer containing N-methylglucamine groups as adsorbent for 68Ge
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DOI：
10.1016/s0969-8043(02)00268-3
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发表时间：
2003-01-01
影响因子：
1.6
通讯作者：
Arano, Y
中科院分区：
文献类型：
--
作者：
Nakayama, M;Haratake, M;Arano, Y
选择了一种含N-甲基葡萄糖胺基团的大孔苯乙烯-二乙烯苯共聚物作为新型Ge-68/Ga-68发生剂体系。这种树脂填充到柱中有效地吸附母体核素Ge-68。用低亲和力镓螯合配体如柠檬酸或磷酸的溶液从树脂洗脱子Ga-68。Ge-680的泄漏量小于吸附量的0.00041%。通过将转铁蛋白和去铁胺缀合的HSA和IgG与来自柱的洗脱液简单混合，以高产率完成Ga-68-标记。(C)2002爱思唯尔科技有限公司版权所有。
A macroporous styrene-divinylbenzene copolymer containing N-methylglucamine groups was selected for a new Ge-68/Ga-68 generator system. This resin packed into a column effectively adsorbed the parent nuclide Ge-68. The daughter Ga-68 was eluted from the resin with a solution of a low-affinity gallium chelating ligand such as citric or phosphoric acid. The Ge-68 leakage was less than 0.00041% of the Ge-680 adsorbed on the resin. By simple mixing of transferrin and desferoxamine conjugated HSA and IgG with the eluate from the column, Ga-68-labeling was completed in high yield. (C) 2002 Elsevier Science Ltd. All rights reserved.