Nutrition as Adjunct Therapy in Periodontal Disease Management
Nutrition as Adjunct Therapy in Periodontal Disease Management
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DOI：
10.1007/s40496-019-0216-4
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发表时间：
2019-06
影响因子：
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通讯作者：
B. Sulijaya;N. Takahashi;Kyoko Yamazaki;K. Yamazaki
中科院分区：
文献类型：
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作者：
B. Sulijaya;N. Takahashi;Kyoko Yamazaki;K. Yamazaki
综述目的牙周病及其相关全身性疾病由于其全球患病率不断增加而引起了公众的关注。尽管如此，治疗牙周炎的黄金标准是洗牙和根面平整术（SRP）。然而，细菌重新定殖被认为是这种方法的限制。此外，抗生素、抗菌剂和益生菌等辅助药物的功效已得到广泛研究。如今，由于抗生素和抗菌药物滥用而导致的耐药性发展已成为一个全球性问题和我们关注的问题。为了减少耐药性发展的蔓延，许多研究都集中在使用营养化合物而不是合成药物来治疗牙周炎（一种相对低度的炎症性疾病）。此外，如果牙周炎被理解为一种细菌失调引起的炎症性疾病，那么其治疗不仅可以消除牙周病原体，还可以改变宿主的免疫反应。因此，这篇综述将强调一些相关营养素对牙周状况的有效性。最新发现众所周知，营养素具有抗炎、抗氧化和抗菌特性，可维持体内平衡。体内和体外研究已经证明营养摄入对维持和恢复牙周健康具有积极作用。人们越来越多地发现维生素、脂肪酸和益生菌具有显着的益处和有价值的特性。总结此外，考虑到口腔系统的联系，鼓励营养补充剂作为改善口腔和全身健康的可能的辅助疗法。
Purpose of ReviewPeriodontal disease and its associated systemic diseases have gained public attention due to their increasing global prevalence. Still, the gold standard for the management of periodontitis is scaling and root planing (SRP). However, bacterial recolonization is considered a limitation of this approach. Further, the efficacy of adjunctive agents such as antibiotics, antimicrobials, and probiotics has been investigated extensively. Nowadays, drug resistance development due to antibiotics and antimicrobials abuse has become a global problem and our concern. In order to reduce the spread of drug resistance development, many investigations have been focused on the use of nutritional compounds rather than synthetic drugs for treating periodontitis, a relatively low-grade inflammatory disease. Moreover, if periodontitis is understood as a bacterial dysbiosis-induced inflammatory disease, then its treatment could be designed not only to eliminate periodontopathogens, but also to modify the host immune response. Therefore, this review will highlight the effectiveness of some pertinent nutrients towards periodontal condition.Recent FindingsNutrients are known to possess anti-inflammatory, antioxidant, and antimicrobial properties that maintain homeostasis. In vivo and in vitro studies have demonstrated the positive effects of nutrient intake on the maintenance and restoration of periodontal health. Vitamins, fatty acids, and probiotics are increasingly being found to have remarkable benefits and valuable properties.SummaryFurther, considering the oral-systemic connection, nutritional supplementation is encouraged as a possible adjunct therapy for the improvement of both oral and systemic health.