Low Survival Rates of Oral and Oropharyngeal Squamous Cell Carcinoma.
Low Survival Rates of Oral and Oropharyngeal Squamous Cell Carcinoma.
复制标题
DOI：
10.1155/2017/5815493
复制
发表时间：
2017
影响因子：
2.1
通讯作者：
Ferreira SMS
中科院分区：
文献类型：
--
作者：
Le Campion ACOV;Ribeiro CMB;Luiz RR;da Silva Júnior FF;Barros HCS;Dos Santos KCB;Ferreira SJ;Gonçalves LS;Ferreira SMS
评估影响口腔和口咽鳞状细胞癌（SCC）预后的流行病学和临床因素。 选择121例口腔和口咽部鳞状细胞癌病例。使用 Kaplan-Meier 方法估计每个变量的生存曲线。应用 Cox 回归模型来评估变量对生存的影响。 在 103 名患者 (85.1%) 中观察到晚期癌症。舌头上的癌症更常见（23.1%）。一年生存率59.9%，两年生存率40.7%，五年生存率27.8%。与酒精摄入量 (p = 0.038)、晚期癌症分期 (p = 0.003) 和不进行手术的手术 (p < 0.001) 相关的存活率显着降低。当这些变量包含在 Cox 回归模型中时，只有手术程序 (p = 0.005) 表现出对生存的显着影响。 研究结果表明，与未接受手术的患者相比，接受手术的患者的生存率更高。低生存率和高比例的晚期诊断表明口腔癌和口咽癌患者应受到更多关注。
To assess the epidemiological and clinical factors that influence the prognosis of oral and oropharyngeal squamous cell carcinoma (SCC). One hundred and twenty-one cases of oral and oropharyngeal SCC were selected. The survival curves for each variable were estimated using the Kaplan-Meier method. The Cox regression model was applied to assess the effect of the variables on survival. Cancers at an advanced stage were observed in 103 patients (85.1%). Cancers on the tongue were more frequent (23.1%). The survival analysis was 59.9% in one year, 40.7% in two years, and 27.8% in 5 years. There was a significant low survival rate linked to alcohol intake (p = 0.038), advanced cancer staging (p = 0.003), and procedures without surgery (p < 0.001). When these variables were included in the Cox regression model only surgery procedures (p = 0.005) demonstrated a significant effect on survival. The findings suggest that patients who underwent surgery had a greater survival rate compared with those that did not. The low survival rates and the high percentage of patients diagnosed at advanced stages demonstrate that oral and oropharyngeal cancer patients should receive more attention.