Stem Cell Niche, the Microenvironment and Immunological Crosstalk
Stem Cell Niche, the Microenvironment and Immunological Crosstalk
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DOI：
10.1038/cmi.2008.13
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发表时间：
2008-04
影响因子：
24.1
通讯作者：
L. Sujata;S. Chaudhuri
中科院分区：
文献类型：
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作者：
L. Sujata;S. Chaudhuri
干细胞的概念、它们的生理存在、复杂的解剖定位、已知和未知的功能，以及它们在再生医学中的独特用途，现在都包含在一个新的问题中：“这些细胞在免疫学上的相容性如何？”事实上，干细胞的医学方面依赖于基于细胞基本特性的大量查询。在任何成功的治疗尝试之前，都非常强调对干细胞的基础研究进行探索。成体干细胞复杂的方面之一是其与微环境相关物（存在合适靶标时的基质细胞）相关的免疫行为。
The concept of stem cells, their physiological existence, the intricate anatomical localization, the known and the unknown functions, and their exclusive utility for the purpose of regenerative medicine, are all now encompassed within an emergent question,‘how compatible these cells are immunologically?’Indeed, the medical aspects of stem cells are dependent on a large number of queries based on the basic properties of the cells. It has greatly been emphasized to probe into the basic research on stem cells before any successful therapeutic attempts are made. One of the intricate aspects of the adult stem cells is its immunological behavior in relation to the microenvironmental associates, the stromal cells in the presence of a suitable target.