Elimination of chloramphenicol, sulphamethoxazole and oxytetracycline in shrimp, Penaeus chinensis following medicated-feed treatment.
Elimination of chloramphenicol, sulphamethoxazole and oxytetracycline in shrimp, Penaeus chinensis following medicated-feed treatment.
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药物饲料处理后中国对虾体内氯霉素、磺胺甲恶唑和土霉素的消除。
DOI：
10.1016/j.envint.2003.08.006
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发表时间：
2004
影响因子：
11.8
通讯作者：
J. Khalid
中科院分区：
文献类型：
--
作者：
Weifen Wang;Hong Lin;C. Xue;J. Khalid
在野外条件下对中国对虾口服给药后氯霉素（CAP）、磺胺甲恶唑（SMZ）和土霉素（OTC）的肌肉残留消耗进行了评估。三组虾在充满海水的水箱中养殖，并分别饲喂含有 2000 mg kg−1CAP、SMZ 和 OTC 的商业药膳，每天两次，持续 3 天。停止用药后以不同时间间隔（0、0.5、1、1.5、2、3、4、8、10、12、16、24、36、48、72、96、120、144、168小时）进行采样。通过HPLC进行药物分析。 CAP的消除半衰期（t1/2）为10.04 h，SMZ的消除半衰期（t1/2）为5.68 h，OTC的消除半衰期为16.12 h。如果将 CAP 的欧盟 MRPL 值 0.3 ng/g 和 SMZ 的 MRL 值 0.1 μg/g 以及 OTC 引用的有鳍鱼肌肉扩展到虾肌肉，则数据外推表明它将在 139.7 小时（95% CI=132.0–144.4 h）、30.6 小时（95% CI=27.2–33.1 h）后通过，虾肌肉中 CAP、SMZ 和 OTC 的停药期分别为 90.3 小时（95% CI=87.9-92.5 小时）。
Muscle residue depletion of chloramphenicol (CAP), sulphamethoxazole (SMZ) and oxytetracycline (OTC) following oral administration was evaluated in shrimp, Penaeus chinensis under field conditions. Three groups of shrimps were cultured in tanks filled with seawater and fed a commercial medicated diet containing 2000 mg kg−1CAP, SMZ and OTC, respectively, twice daily for 3 days. Sampling was conducted at different intervals (0, 0.5, 1, 1.5, 2, 3, 4, 8, 10, 12, 16, 24, 36, 48, 72, 96, 120, 144, 168 h) after the cessation of medication. Drug analysis was carried out by HPLC. The elimination half-life (t1/2) of CAP was 10.04 h, the elimination half-life (t1/2) of SMZ was 5.68 h and that of OTC was 16.12 h. If the EU MRPL value of 0.3 ng/g for CAP and MRL value of 0.1 μg/g for SMZ and OTC quoted for muscle from finfish is extended to shrimp muscle, extrapolation of the data indicates that it would be passed after a 139.7 h (95% CI=132.0–144.4 h), 30.6 h (95% CI=27.2–33.1 h), 90.3 h (95% CI=87.9–92.5 h) withdrawal period for CAP, SMZ and OTC in shrimp muscle, respectively.